磷酸咪康唑 L-赖氨酸乙醇
| 中文名称 | 磷酸咪康唑 L-赖氨酸乙醇 |
|---|---|
| 中文同义词 | 磷酸咪康唑 L-赖氨酸乙醇;化合物T8847 |
| 英文名称 | Fosravuconazole L-lysine ethanolate |
| 英文同义词 | L-Lysine, coMpd. with 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-1-Methyl-2-[(phosphonooxy)Methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile and ethanol (1:1:1) (9CI);Fosravuconazole L-lysine ethanolate;BMS-379224 L-lysine ethanolate;E-1224 L-lysine ethanolate;Fungal,onychomycosis,Fosravuconazole Llysine ethanolate,Parasite,parasitemia,inhibit,Fosravuconazole L lysine ethanolate,antifungal,Ravuconazole,Inhibitor,candidiasis,Fosravuconazole L-lysine;(S)-2,6-Diaminohexanoic acid (((2R,3R)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl)oxy)methyl dihydrogen phosphate and ethanol salt |
| CAS号 | 914361-45-8 |
| 分子式 | C31H40F2N7O8PS |
| 分子量 | 739.73 |
| EINECS号 | |
| 相关类别 | API |
| Mol文件 | 914361-45-8.mol |
| 结构式 |  |
磷酸咪康唑 L-赖氨酸乙醇 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMSO：50 mg/mL（67.59 mM；需要超声波）| （不溶） |
| 形态 | 固体 |
| 颜色 | 白色至黄色 |
| 水溶解性 | Water : < 0.1 mg/mL (ultrasonic) |
Fosravuconazole L-lysine ethanolate (BMS-379224 L-lysine ethanolate)，Ravuconazole 的前药，是一种具有口服活性的广谱抗真菌剂。Fosravuconazole L-lysine ethanolate 可用于念珠菌病，灰指甲病和寄生虫病的研究。
Fosravuconazole has potent in vitro antifungal activity against a wide range of fungal species, including Candida , Aspergillus , and Trichophyton species.
Fosravuconazole (E-1224; 10-50 mg/kg; oral administration; daily; for 20 days) treatment suppresses the parasitemia and prevents death in mice infected with the T. cruzi Y strain.
| Animal Model: | Swiss female mice (20-24 g) inoculated with trypomastigotes (Y strain). |
| Dosage: | 10 mg/kg, 20 mg/kg, 30 mg/kg, 40 mg/kg, 50 mg/kg |
| Administration: | Oral administration; daily; for 20 days |
| Result: | Suppressed the parasitemia and prevented death. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-16779B | 磷酸咪康唑 L-赖氨酸乙醇 Fosravuconazole L-lysine ethanolate | 914361-45-8 | 10mg | 2400元 |
| 2024/04/30 | HY-16779B | 磷酸咪康唑 L-赖氨酸乙醇 Fosravuconazole L-lysine ethanolate | 914361-45-8 | 25mg | 4640元 |