| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Bisindolylmaleimide XI hydrochloride
CAS:151342-35-7
Package:1mg, 5mg
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:Ro 32-0432 hydrochloride;3-[(8S)-8-[(DiMethylaMino)Methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride
CAS:151342-35-7
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Chemsky (shanghai) International Co.,Ltd
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| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:BisindolylMaleiMide XI Hydrochloride;3-[8-[(DiMethylaMino)Methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione Hydrochloride; Ro 31-0432
CAS:151342-35-7
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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| | RO-32-0432 Basic information |
| Product Name: | RO-32-0432 | | Synonyms: | RO-32-0432;RO 32-0432 HCL;RO 32-0432 HYDROCHLORIDE;BISINDOLYLMALEIMIDE XI, HCL;BISINDOLYLMALEIMIDE XI HYDROCHLORIDE;BISINDOLYLMALEIMIDE XL, HCL;BISINDOYLMALEIMIDE XI HYDROCHLORIDE;2-[8-[(DIMETHYLAMINO)METHYL]-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL)MALEIMIDE, HCL | | CAS: | 151342-35-7 | | MF: | C28H28N4O2 | | MW: | 452.55 | | EINECS: | | | Product Categories: | inhibitor | | Mol File: | 151342-35-7.mol |  |
| | RO-32-0432 Chemical Properties |
| Boiling point | 712.2±60.0 °C(Predicted) | | density | 1.32±0.1 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | DMSO: soluble | | form | solid | | pka | 7.91±0.60(Predicted) | | color | orange |
| WGK Germany | 3 | | HS Code | 3822000000 |
| | RO-32-0432 Usage And Synthesis |
| Uses | Bisindolylmaleimide XI is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCα by Bisindolylmaleimide XI and other similar PKC inhibitors has
been associated with enhanced cardiac contractility and protection from heart failure. Bisindolylmaleimide XI has been shown to prevent T-cell activation and proliferation associated with chronic infl
ammatory responses in vivo. | | Biological Activity | Selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca 2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α , β Ι, β ΙΙ, γ and ε respectively. Orally available and prevents T-cell chronic inflammation in vivo . |
| | RO-32-0432 Preparation Products And Raw materials |
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