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| | 8-OXO-2'-DEOXYGUANOSINE Basic information |
| | 8-OXO-2'-DEOXYGUANOSINE Chemical Properties |
| Melting point | 217-220°C | | density | 2.25±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO (up to 10 mg/ml). | | pka | 7.86±0.20(Predicted) | | form | White to off-white solid. | | color | Off-white | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| Safety Statements | 24/25 | | WGK Germany | 3 | | RTECS | MF8782675 | | HS Code | 29349990 |
| | 8-OXO-2'-DEOXYGUANOSINE Usage And Synthesis |
| Description | 8-Oxo-2′-deoxyguanosine (88847-89-6) is a useful marker for DNA damage via a variety of oxidative processes.1?It is a critical biomarker for oxidative stress and carcinogenesis.2,3 | | Chemical Properties | White Crystalline Solid | | Uses | 8-Hydroxy-2′-deoxyguanosine has been used:
- as a standard to analyse the oxidative DNA damage in the placenta of normal and abnormal pregnancies by electrochemical detection
- as a standard for high performance liquid chromatography (HPLC) with electrochemical detection (ECD) measurement
- as a standard for HPLC and as a urinary marker of oxidative stress in order to assess the potential?antioxidant?activity of green coffee bean extract (GCBE) in vivo
- as a standard for LC/MS/MS analysis
| | Uses | A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro. | | Definition | ChEBI: Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage. | | Biochem/physiol Actions | A marker compound typically indicative of DNA damage associated with mutagenesis and carcinogenesis | | References | 1) Beckman?et al. (1997),?Oxidative decay of DNA; J. Biol. Chem.,?272?19636
2) Andreoli?et al. (2010),?Quantitative determination of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine, 8-oxo-7,8-dihydroguanine, 8-oxo-7,8-dihydroguanosine, and their non-oxidized forms: daily concentration profile for healthy volunteers; Biomarkers,?15?221
3) Manini?et al. (2009),?Biomarkers of nucleic acid oxidation, polymorphism in, and expression of, hOGG1 gene in styrene-exposed workers; Toxicol. Lett.,?190?41 |
| | 8-OXO-2'-DEOXYGUANOSINE Preparation Products And Raw materials |
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