5-氯-6-[(2-亚氨基-1-吡咯烷基)甲基]-2,4(1H,3H)-嘧啶二酮
| 中文名称 | 5-氯-6-[(2-亚氨基-1-吡咯烷基)甲基]-2,4(1H,3H)-嘧啶二酮 |
|---|---|
| 中文同义词 | 替比拉西;替吡嘧啶;5-氯-6-[(2-亚氨基-1-吡咯烷基)甲基]-2,4(1H,3H)-嘧啶二酮;化合物 TIPIRACIL |
| 英文名称 | 5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione, |
| 英文同义词 | 5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione,;5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione;MA 1 (pharmaceutical);TPI (thymidine phosphorylase inhibitor);2,4(1H,3H)-Pyrimidinedione, 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-;2,4(1H,3H)-Pyrimidinedione, 5-chloro-6-[(2-imino-1-pyrrolidi...;Tipiracil D4Q: What is Tipiracil D4 Q: What is the CAS Number of Tipiracil D4 |
| CAS号 | 183204-74-2 |
| 分子式 | C9H11ClN4O2 |
| 分子量 | 242.66 |
| EINECS号 | |
| 相关类别 | 抗肿瘤药物 |
| Mol文件 | 183204-74-2.mol |
| 结构式 | ![5-氯-6-[(2-亚氨基-1-吡咯烷基)甲基]-2,4(1H,3H)-嘧啶二酮 结构式](CAS/20180703/GIF/183204-74-2.gif) |
5-氯-6-[(2-亚氨基-1-吡咯烷基)甲基]-2,4(1H,3H)-嘧啶二酮 性质
| 密度 | 1.71±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 水：1mg/mL（4.12mM）； DMSO：< 1 mg/mL（不溶或微溶） |
| 酸度系数(pKa) | 7.06±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
Tipiracil 是一种胸苷磷酸化酶 (TPase) 抑制剂。
thymidine phosphorylase
Tipiracil is an inhibitor of thymidine phosphorylase. Tipiracil increases trifluridine exposure by inhibiting its metabolism by thymidine phosphorylase. The combination of Trifluridine and Tipiracil is a new oral treatment for metastatic colorectal cancer. Tipiracil prevents degradation of FTD through a first-pass effect as a thymidine phosphorylase inhibitor.