硫替丁
中文名称 | 硫替丁 |
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中文同义词 | 硫替丁;化合物 T13163 |
英文名称 | TIOTIDINE |
英文同义词 | TIOTIDINE;N-[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazoyl]methyl]thio]ethyl]-N'-cyano-N''-methylguanidine;1-Methyl-2-cyano-3-[2-[[2-(diaminomethyleneamino)thiazole-4-yl]methylthio]ethyl]guanidine;1-Methyl-2-cyano-3-[2-[2-(diaminomethyleneamino)thiazole-4-ylmethylthio]ethyl]guanidine;ICI-125211;N-[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]-N'-cyano-N''-methylguanidine;N'-Cyano-N-[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]-N''-methylguanidine;1-[2-[[2-[bis(azanyl)methylideneamino]-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-3-cyano-2-methyl-guanidine |
CAS号 | 69014-14-8 |
分子式 | C10H16N8S2 |
分子量 | 312.42 |
EINECS号 | |
相关类别 | Histamine receptor |
Mol文件 | 69014-14-8.mol |
结构式 |
硫替丁 性质
沸点 | 490.1±55.0 °C(Predicted) |
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密度 | 1.50±0.1 g/cm3(Predicted) |
储存条件 | Store at RT |
溶解度 | 在乙醇中溶解度为 10 mM,在 DMSO 中溶解度为 100 mM |
形态 | 粉末 |
酸度系数(pKa) | pKa 6.80 (Uncertain) |
颜色 | 白色至黄色 |
H 2 Receptor 7.3-7.8 (pA2) |
H 3 Receptor 4.8 (pA2) |
Tiotidine competitively antagonizes the positive chronotropic action of histamine with an apparent dissociation constant of 30 μM (23-38 μM). Tiotidine abolishes H2-mediated increases in contractile force leaving H2-mediated negative inotropic responses unopposed. The actions of histamine at the A-V node, manifested by lengthening of the P-R interval and A-V block, are attenuated by 2.5 x 10(-7) M Tiotidine.
Tiotidine actually behaves as an inverse agonist in U-937 cells, diminishing basal cAMP levels.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-101232 | 硫替丁 Tiotidine | 69014-14-8 | 1mg | 545元 |
2024/04/30 | HY-101232 | 硫替丁 Tiotidine | 69014-14-8 | 5mg | 1200元 |