- Propargyl-PEG5-amine
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- $0.00 / 1Kg
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2024-12-24
- CAS:1589522-46-2
- Min. Order: 1Kg
- Purity: 99.9%
- Supply Ability: 200tons
- Propargyl-PEG5-amine
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- $0.00 / 100mg
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2024-10-28
- CAS:1589522-46-2
- Min. Order:
- Purity:
- Supply Ability: 10g
- Propargyl-PEG5-amine
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- $0.00 / 5g
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2024-03-26
- CAS:1589522-46-2
- Min. Order: 5g
- Purity: >98.00%
- Supply Ability: 5g
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| | Propargyl-PEG5-amine Basic information |
| Product Name: | Propargyl-PEG5-amine | | Synonyms: | Propargyl-PEG5-amine;HC≡C-CH2-PEG6-NH2;Alkyne-PEG5-NH2;PROPARGYL-PEG5-NH2;3,6,9,12,15-Pentaoxaoctadec-17-yn-1-amine;Propargyl-PEG5-NH2/3,6,9,12,15-Pentaoxaoctadec-17-yn-1-amine;2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethanamine | | CAS: | 1589522-46-2 | | MF: | C13H25NO5 | | MW: | 275.34 | | EINECS: | | | Product Categories: | PROTAC Linker;PROTAC;peg | | Mol File: | 1589522-46-2.mol |  |
| | Propargyl-PEG5-amine Chemical Properties |
| Boiling point | 360.4±37.0 °C(Predicted) | | density | 1.049±0.06 g/cm3(Predicted) | | solubility | DMSO : 100 mg/mL (363.19 mM; Need ultrasonic) | | pka | 8.74±0.10(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | Propargyl-PEG5-amine Usage And Synthesis |
| Description | Propargyl-PEG5-amine is a propargyl linker that is commonly used as a Click Chemistry reagent for copper-catalyzed reactions with azides. The amine moiety reacts with carboxylic acids, activated NHS esters and other carbonyl compounds. The PEG spacer helps improve the water solubility of the molecule in aqueous media. | | Biological Activity | Propargyl-PEG5-amine is a non-cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PROTAC linker belonging to the PEG class and can be used to synthesize a series of PROTAC molecules. | | in vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. | | target | | Non-cleavable < span> | PEGs | |
| | Propargyl-PEG5-amine Preparation Products And Raw materials |
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