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| | UNC3230 Basic information |
| Product Name: | UNC3230 | | Synonyms: | UNC3230;2-anilino-5-(cyclohexanecarbonylamino)-1,3-thiazole-4-carboxamide;5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide;4-Thiazolecarboxamide, 5-[(cyclohexylcarbonyl)amino]-2-(phenylamino)-;5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide;hyperalgesia,thermal,UNC3230,DRG,antinociceptive,neuron,inhibit,UNC-3230,PIP2,anticancer,glycolysis,PIP4K2C,PIP5K1C,Inhibitor | | CAS: | 1031602-63-7 | | MF: | C17H20N4O2S | | MW: | 344.43 | | EINECS: | | | Product Categories: | | | Mol File: | 1031602-63-7.mol |  |
| | UNC3230 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO:30.0(Max Conc. mg/mL);87.1(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);87.1(Max Conc. mM)
Ethanol:0.2(Max Conc. mg/mL);0.58(Max Conc. mM) | | form | A crystalline solid | | color | Off-white to light yellow |
| | UNC3230 Usage And Synthesis |
| Description | Phosphatidylinositol-4-phosphate 5-kinase type-1 γ (PIP5K1C) is a lipid kinase that generates phosphatidylinositol-4,5-bisphosphate (PIP2) in nociceptive dorsal root ganglia (DRG). Pain sensitization is regulated by multiple signaling pathways that are initiated by phospholipase C-mediated hydrolysis of PIP2. UNC3230 is a small molecule inhibitor of PIP5K1C (IC50 = 41 nM, Kd = 51 nM). It does not inhibit any other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 3-kinases. At 100 nM, UNC3230 decreases PIP2 membrane levels in cultured DRG neurons by 45% and significantly reduces calcium signaling. At 2 nM, it displays antinociceptive effects in mouse models of chronic pain when administered intrathecally or injected into inflamed hindpaw. | | Uses | UNC 3230 is a potent inhibitor of PIP5K1C. | | storage | Store at +4°C |
| | UNC3230 Preparation Products And Raw materials |
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