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UNC0321

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Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:UNC0321/ (trifluoroacetate salt)
CAS:1238673-32-9
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd.
Tel: 0431-80514535 13634302652
Email: Extension@chemextension.com
Products Intro: Product Name:7-{2-[2-(dimethylamino)ethoxy]ethoxy}-6-methoxy-2-(4-methyl-1,4-d Iazepan-1-yl)-n-(1-methyl-4-piperidinyl)-4-quinazolinamine
CAS:1238673-32-9
Purity:98%+ Package:500MG;1G;5G;25G Remarks:Advantage of COF&MOF ligand manufacturers, related products can be provided
Company Name: Shanghai Daeyeon Chemicals Co., Ltd
Tel: 021-64478606 +8615900664856
Email: daeyeon001@vip.163.com
Products Intro: Product Name:7-{2-[2-(dimethylamino)ethoxy]ethoxy}-6-methoxy-2-(4-methyl-1,4-d Iazepan-1-yl)-n-(1-methyl-4-piperidinyl)-4-quinazolinamine
CAS:1238673-32-9
Purity:98.0%
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:UNC0321
CAS:1238673-32-9
Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；200 mg；25 mg；5 mg；50 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 15093356674;
Email: laboratory@coreychem.com
Products Intro: Product Name:UNC0321
CAS:1238673-32-9
Purity:98%; CR LIU Package:1KG;0.01USD
UNC0321 Basic information
Product Name:UNC0321
Synonyms:UNC0321;7-(2-(2-(diMethylaMino)ethoxy)ethoxy)-6-Methoxy-2-(4-Methyl-1,4-diazepan-1-yl)-N-(1-Methylpiperidin-4-yl)quinazolin-4-aMine;7-[2-[2-(Dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine;UNC0321(UNC-0321);UNC 0321; UNC-0321; UNC0321; UNC-0321;4-Quinazolinamine, 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-;H3K9me2,SAR,PKMT,Histone Methyltransferase,H3K9,quinazoline,inhibit,K373,UNC-0321,p53,UNC0321,UNC 0321,G9a,GLP,Inhibitor
CAS:1238673-32-9
MF:C27H45N7O3
MW:515.69
EINECS:604-604-1
Product Categories:
Mol File:1238673-32-9.mol
UNC0321 Structure
UNC0321 Chemical Properties
Boiling point 664.7±65.0 °C(Predicted)
density 1.150±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: ≥ 31 mg/mL (60.11 mM)
pka9.34±0.70(Predicted)
form Powder
Safety Information
MSDS Information
UNC0321 Usage And Synthesis
DefinitionChEBI: 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methyl-4-piperidinyl)-4-quinazolinamine is a member of quinazolines.
Biological ActivityUNC0321 is a potent and selective histone methyltransferase G9a inhibitor with Ki of 63 pM and IC50 of 6-9 nM.It also inhibits GLP with IC50 values of 15-23 nM.UNC0321 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E.
in vitro

In G9a ECSD and CLOT assays, the IC 50 values of 9 nM and 6 nM for UNC0321 (Compound 29), respectively. In GLP ECSD and CLOT assays, the IC 50 values of 15 nM and 23 nM for UNC0321, respectively.
UNC0321 (Compound 3) reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 11 μM.

target

G9a

63 pM (Ki)

G9a

6-9 nM (IC 50 )

GLP

15-23 nM (IC 50 )

UNC0321 Preparation Products And Raw materials
Tag:UNC0321(1238673-32-9) Related Product Information
UNC 1999 UNC0379 UNC569 UNC0638 UNC 0224 UNC-0642 UNC 0631 HA-15 CPI-455 Maritoclax GDC-0623 IMR-1 CHIR 99021 trihydrochloride CEP-18770 LJI308 2-((2-Chlorophenyl)(phenyl)aMino)-N-(7-(hydroxyaMino)-7-oxoheptyl)pyriMidine-5-carboxaMide AZ191 HTH-01-015