IMR-1

IMR-1 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:IMR-1
CAS:310456-65-6
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:IMR-1
CAS:310456-65-6
Purity:>98% Package:25mg Remarks:BOC Sciences also provides custom synthesis services for IMR-1.
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: factory@coreychem.com
Products Intro: Product Name:IMR-1
CAS:310456-65-6
Purity:99% Package:1KG;7USD
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:IMR-1
CAS:310456-65-6
Purity:99% Package:5KG;1KG Remarks:IMR-1
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:IMR-1
CAS:310456-65-6
Purity:98% Package:5mg Remarks:V19757

IMR-1 manufacturers

  • IMR-1
  • IMR-1 pictures
  • $7.00 / 1KG
  • 2020-01-14
  • CAS:310456-65-6
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 1000kg
IMR-1 Basic information
Product Name:IMR-1
Synonyms:IMR-1;[2-Methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]acetic acid ethyl ester;IMR-1, >98%;Acetic acid, 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-, ethyl ester;IMR-1 >=98% (HPLC);2-Methoxy-4-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenoxy]-acetic acid ethyl ester;IMR 1,IMR1,IMR-1,Notch,Inhibitor,inhibit;2-Methoxy-4-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenoxy]-acetic acid ethyl este,IMR-1
CAS:310456-65-6
MF:C15H15NO5S2
MW:353.41
EINECS:
Product Categories:
Mol File:310456-65-6.mol
IMR-1 Structure
IMR-1 Chemical Properties
storage temp. 2-8°C(protect from light)
solubility Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 9 mg/ml with warming).
form solid
color Yellow
Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Safety Information
MSDS Information
IMR-1 Usage And Synthesis
DescriptionInhibitor of Mastermind Recruitment-1 (IMR-1, 310456-65-6) disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex (NTC) on chromatin, which attenuates Notch target gene transcription.1?IC50=26 μM (in vitro assay). IMR-1 inhibits the growth of Notch-dependent cell lines and attenuates the growth of patient-derived tumor xenografts. The ethyl ester is hydrolyzed by intracellular esterases which produces the free acid compound (IMR-1A), IC50=0.5 μM (in vitro?assay). Binding of IMR-1 to NTC is non-covalent and reversible.1
in vitroin order to determine the effect of imr-1 on the assembly of the notch ternary complex (ntc) in cells, notch-dependent cell lines oe33 and 786-0 were treated with imr-1 or dapt. results showed that treatment of oe33 and 786-0 with imr-1 could decrease the occupancy of maml1 on the hes1 promoter but, in contrast to dapt, imr-1 treatment could not affect the occupancy of notch1 on the hes1 promoter. in addition, western blot analyses indicated that imr-1 treatment did not change the cellular levels of nicd [1].
in vivoanimal study showed that treatment of mice with 15 mg/kg imr-1 could readily block tumor establishment. moreover, imr-1 treatment at 15 mg/kg caused no observable adverse effects on the animal. in two independent pdx models, imr-1 could significantly abrogate the tumor growth to a similar level achieved with dapt treatment, without any significant weight loss or other visible signs of adverse effects in the treated mice [1].
IC 5026 μmol/l
References1) Austudilo?et al.?(2016),?The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis; Cancer Res.,?76?3593
IMR-1 Preparation Products And Raw materials
Tag:IMR-1(310456-65-6) Related Product Information
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