HA-15

HA-15 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: CAS:1609402-14-3
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:HA15
CAS:1609402-14-3
Purity:99.86% Package:1mg;34USD|2mg;47USD|5mg;76USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695
Email: laboratory@coreychem.com
Products Intro: Product Name:HA-15
CAS:1609402-14-3
Purity:95%-99% 604crystal Package:1KG;0.01USD
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:HA15
CAS:1609402-14-3
Purity:98% Package:5mg Remarks:V2891
Company Name: Nanjing Doge Biomedical Technology Co., Ltd
Tel: +86-25-58227606 +86-15305155328
Email: sales@dogechemical.com
Products Intro: Product Name:HA-15
CAS:1609402-14-3
Package:5g;100g;1KG;25KG

HA-15 manufacturers

  • HA15
  • HA15 pictures
  • $34.00 / 1mg
  • 2024-10-31
  • CAS:1609402-14-3
  • Min. Order:
  • Purity: 99.86%
  • Supply Ability: 10g
HA-15 Basic information
Product Name:HA-15
Synonyms:HA-15;CS-2893;HA15;HA 15;Acetamide, N-[4-[3-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-thiazolyl]-;HA15 >=98% (HPLC);N-(4-(3-((5-(Dimethylamino)naphthalene)-1-sulfonamido)phenyl)thiazol-2-yl)acetamide;HA-15,HSP,HA 15,Inhibitor,HA15,Apoptosis,inhibit,Autophagy,Heat shock proteins
CAS:1609402-14-3
MF:C23H22N4O3S2
MW:466.58
EINECS:604-604-1
Product Categories:
Mol File:1609402-14-3.mol
HA-15 Structure
HA-15 Chemical Properties
density 1.406±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:71.5(Max Conc. mg/mL);153.24(Max Conc. mM)
Ethanol:45.0(Max Conc. mg/mL);96.45(Max Conc. mM)
form A solid
pka7.32±0.50(Predicted)
color Light yellow to green yellow
Safety Information
MSDS Information
HA-15 Usage And Synthesis
DefinitionChEBI: HA15 is a sulfonamide resulting from the formal condensation of the sulfonic acid group of 5-(dimethylamino)naphthalene-1-sulfonic acid with the aniline nitrogen of 3-(2-acetamido-1,3-thiazol-4-yl)aniline. It has been reported that by triggering an endoplasmic reticulum (ER) stress response, HA15 can reduce the viability of melanoma cells without being toxic to normal cells. It has a role as an antineoplastic agent. It is a sulfonamide, a member of 1,3-thiazoles, a member of acetamides, a tertiary amino compound, an aminonaphthalene and a biaryl.
Biological ActivityHA15 is a small molecule that specifically targets HSPA5 (Heat shock 70kDa protein 5), also known as BiP (Immunoglobulin heavy-chain-binding protein) or Grp78 (glucose-regulated protein 78). Antitumor activity in melanoma cells tested, including cells isolated from patients and cells resistant to BRAF inhibitors.
in vitro

HA15 induces endoplasmic reticulum stress in cells in vitro, leading to cancer cell death; in melanoma cells, it overcomes its resistance to BRAF inhibitors.

in vivoIn xenograft mouse models (bearing melanoma cells sensitive or resistant to BRAF inhibitors), HA15 was able to induce endoplasmic reticulum stress leading to cancer cell death.
target
TargetValue
BiP/GRP78/HSPA5
()
HA-15 Preparation Products And Raw materials
Tag:HA-15(1609402-14-3) Related Product Information
UNC0321 CPI-455 Maritoclax GDC-0623 IMR-1 CHIR 99021 trihydrochloride CEP-18770 LJI308 2-((2-Chlorophenyl)(phenyl)aMino)-N-(7-(hydroxyaMino)-7-oxoheptyl)pyriMidine-5-carboxaMide AZ191 HTH-01-015 GDC-0879 4-iodo-3-nitrobenzamide VBY-825