- Ormetoprim
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- $0.00 / 1Kg/Bag
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2025-04-16
- CAS:6981-18-6
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 1000kgs
- Ormetoprim
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- $40.00 / 5mg
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2024-11-19
- CAS:6981-18-6
- Min. Order:
- Purity: 99.78%
- Supply Ability: 10g
- Ormetoprim
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- $1.00 / 1KG
-
2020-02-05
- CAS:6981-18-6
- Min. Order: 1KG
- Purity: Min98% HPLC
- Supply Ability: g/kg/ton
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| | 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Basic information |
| | 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Chemical Properties |
| Melting point | 231.0 to 235.0 °C | | Boiling point | 521.5±60.0 °C(Predicted) | | density | 1.223±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated) | | form | Solid | | pka | 7.11±0.10(Predicted) | | color | Off-White | | Water Solubility | Water: Insoluble | | λmax | 287nm(CHCl3)(lit.) | | Stability: | Hygroscopic | | CAS DataBase Reference | 6981-18-6(CAS DataBase Reference) | | EPA Substance Registry System | Ormetoprim (6981-18-6) |
| Safety Statements | 24/25 | | HS Code | 29333990 |
| | 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Usage And Synthesis |
| Uses | It is a potent and selective inhibitor of bacterial dihydrofolate reductase, the enzyme responsible for the NADPH-dependent reduction of 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. Antibacterial.This compound is a contaminant of emerging concern (CECs). | | Definition | ChEBI: 5-[(4,5-dimethoxy-2-methylphenyl)methyl]pyrimidine-2,4-diamine is a dimethoxybenzene. | | Synthesis Reference(s) | Journal of Medicinal Chemistry, 14, p. 462, 1971 DOI: 10.1021/jm00287a029 | | in vivo | Ormetoprim (8.3 mg/kg; i.p.) exhibits absorption half-life (5.4 h), elimination half-life (7.5 h) and Cmax (1.2±0.2 μg/mL)[3].
Ormetoprim (8.3 mg/kg; p.o.) exhibits absorption half-life (3.9 h), elimination half-life (3.9 h), Cmax (1.6±0.4 μg/mL) and oral availability (78.5%) relative to intraperitoneal administration[3]. | Animal Model: | Hybrid striped bass (565-805 g)[3] | | Dosage: | 50 mg/kg Sulfadimethoxine and Ormetoprim in a 5:1 ratio (Pharmacokinetic Analysis) | | Administration: | I.p. and p.o. administration | | Result: | I.p.: t1/2(elim)=7.5 h; t1/2(abs)=5.4 h; Cmax=1.2 μg/mL.
P.o.: t1/2(elim)=3.9 h; t1/2(abs)=3.9 h; Cmax=1.6 μg/mL; F=78.5%.
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| | 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Preparation Products And Raw materials |
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