| Company Name: |
GL Biochem (Shanghai) Ltd
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| Tel: |
21-61263452 13641803416 |
| Email: |
ymbetter@glbiochem.com |
| Products Intro: |
Product Name:(D-Pen2,Pen5)-Enkephalin
CAS:88373-72-2
Purity:95% HPLC,98% HPLC Package:10mg, 25mg, 50mg, 100mg, 500mg, 1g,10g
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| Company Name: |
Shanghai Hanhong Scientific Co.,Ltd.
|
| Tel: |
021-54306202 13764082696 |
| Email: |
info@hanhongsci.com |
| Products Intro: |
Product Name:(D-Pen2,Pen5)-Enkephalin
CAS:88373-72-2
Remarks:332P2290
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| | (D-PEN2,PEN5)-ENKEPHALIN Basic information |
| Product Name: | (D-PEN2,PEN5)-ENKEPHALIN | | Synonyms: | TYR-D-PEN-GLY-PHE-PEN;L-Tyr-D-Pen-Glu-L-Phe-L-Pen-OH;Tyr-D-Pen-Gly-Phe-D-Pen (Disulfide bridge D-Pen2-D-Pen5);(D-PEN2,PEN5)-ENKEPHALIN;[D-PEN2,L-PEN5]-ENKEPHALIN;DPLPE;H-TYR-D-PEN-GLY-PHE-PEN-OH;H-Tyr-D-Pen-Gly-Phe-Pen-OH (Disulfide bond) | | CAS: | 88373-72-2 | | MF: | C30H39N5O7S2 | | MW: | 645.79 | | EINECS: | | | Product Categories: | | | Mol File: | 88373-72-2.mol |  |
| | (D-PEN2,PEN5)-ENKEPHALIN Chemical Properties |
| storage temp. | −20°C | | form | Solid |
| | (D-PEN2,PEN5)-ENKEPHALIN Usage And Synthesis |
| Uses | [DPen2, Pen5] Enkephalin is a δ-opioid receptor selective analog of [Leu5]-Enkephalin.html" class="link-product" target="_blank">[Leu5]-Enkephalin (HY-P0288)[1]. | | in vivo | [DPen2, Pen5] Enkephalin (0-3.32 μg/kg, IP) impairs acquisition of an automated jump-up avoidance response in rats and acquisition of a one-way active avoidance response in mice[1]. | Animal Model: | Male Sprague-Dawley rats (260-280 g)[1] | | Dosage: | 0, 1.16, 11.6 μg/kg | | Administration: | IP, administered on day 2 prior to presentation of eight training trials, on subsequent one-way avoidance responding. | | Result: | Produced a significant impairment of avoidance performance at 1.16 ug/kg, while the 11.6 ug/kg dose was without significant effect. |
| Animal Model: | Male Sprague-Dawley rats (260-280 g)[1] | | Dosage: | 0, 0.332, 3.32 μg/kg | | Administration: | IP, administered on day 1 immediately after presentation of two escape-only trials, on subsequent day 2 one-way avoidance responding in the second experiment | | Result: | Produced a significant enhancement of avoidance performance at 0.332 ug/kg, while the 3.32 ug/kg dose was without significant effect. |
| | IC 50 | δ Opioid Receptor/DOR | | References | [1] Martinez JL Jr, et al. D-Pen2-[D-Pen5]enkephalin impairs acquisition and enhances retention of a one-way active avoidance response in rats. Peptides. 1992 Sep-Oct;13(5):885-9. DOI:10.1016/0196-9781(92)90045-5 |
| | (D-PEN2,PEN5)-ENKEPHALIN Preparation Products And Raw materials |
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