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| L-NORADRENALINE BITARTRATE Basic information |
| L-NORADRENALINE BITARTRATE Chemical Properties |
storage temp. | Store at 4°C, protect from light | solubility | 31.93mg/mL in DMSO | pka | 8.64(at 25℃) | Melting point | 102-104 °C | Water Solubility | 31.93mg/mL in Water | CAS DataBase Reference | 51-40-1(CAS DataBase Reference) |
RIDADR | 3249 | HazardClass | 6.1(b) | PackingGroup | III | Toxicity | LD50 ivn-rat: 210 mg/kg YACHDS 7,627,79 |
| L-NORADRENALINE BITARTRATE Usage And Synthesis |
Uses | Adrenergic (vasoconstrictor). | Brand name | Levophed (Hospira). | Clinical Use | Hypotension
Cardiac arrest (sympathomimetic) | Safety Profile | Poison by intravenous andintraperitoneal routes. When heated to decomposition itemits toxic fumes of NOx. | Drug interactions | Potentially hazardous interactions with other drugs
Adrenergic neurone blockers: antagonise hypotensive
effect.
Anaesthetics: increased risk of arrhythmias with
volatile general anaesthetics.
Antidepressants: tricyclics may cause hypertension
and arrhythmias; MAOIs and moclobemide may
cause hypertensive crisis.
Beta-blockers: can cause severe hypertension.
Clonidine: possibly increased risk of hypertension.
Dopaminergics: effects possibly increased by
entacapone; avoid with rasagiline.
Sympathomimetics: effects possibly enhanced by
dopexamine. | Metabolism | Extensively metabolised by catechol-O-methyltransferase
(COMT), and monoamine oxidase (MAO).
Up to 16% of an intravenous dose is excreted unchanged
in the urine with methylated and deaminated metabolites
in free and conjugated forms. | storage | Store at +4°C |
| L-NORADRENALINE BITARTRATE Preparation Products And Raw materials |
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