AT-1002 manufacturers
- AT-1002
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- $10.00 / 1KG
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2024-04-28
- CAS:835872-35-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | AT-1002 Basic information |
| Product Name: | AT-1002 | | Synonyms: | AT-1002;L-Phenylalanyl-L-cysteinyl-L-isoleucylglycyl-L-arginyl-L-leucine;L-Leucine, L-phenylalanyl-L-cysteinyl-L-isoleucylglycyl-L-arginyl- | | CAS: | 835872-35-0 | | MF: | C32H53N9O7S | | MW: | 707.88 | | EINECS: | | | Product Categories: | | | Mol File: | 835872-35-0.mol |  |
| | AT-1002 Chemical Properties |
| density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 3.38±0.10(Predicted) |
| | AT-1002 Usage And Synthesis |
| Description | AT-1002, a 6-mer synthetic peptide[1], is a tight junction regulator and absorption enhancer[2]. AT-1002, a 6-mer synthetic peptide, belongs to an emerging novel class of compounds that reversibly increase paracellular transport of molecules across the epithelial barrier. AT-1002 can undergo Cys-Cys dimerization[1].Undifferentiated Caco-2 cells are treated with AT-1002 (0 to 5 mg/mL, 3 or 24 hours) and viability is assessed by measuring cellular ATP content. Treatment with AT-1002 for up to 3 h does not affect cell viability at any concentration. In particular, the viability of Caco-2 cells is not affected by 5 mg/mL AT-1002. AT-1002 reduces cell viability after 24 h at concentrations of 2.5 mg/mL and higher. However, the cells remain viable after 24 h if the cells are washed after exposure to AT-1002 for 3 h indicating that AT-1002 does not irreversibly damage cells[2].|| Cell Viability Assay[2]||Cell Line:|Caco-2 cells|Concentration:|0 to 5 mg/mL |Incubation Time:|3 or 24 hours|Result:|Treatment for up to 3 h did not affect cell viability at any concentration. Reduced cell viability after 24 h at concentrations of 2.5 mg/mL and higher. | | References | [1]. Li M, et al. Structure-activity relationship studies of permeability modulating peptide AT-1002. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4584-6. [2]. Gopalakrishnan S, et al. Mechanism of action of ZOT-derived peptide AT-1002, a tight junction regulator and absorption enhancer. Int J Pharm. 2009 Jan 5;365(1-2):121-30. |
| | AT-1002 Preparation Products And Raw materials |
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