![AT-1002](/ProductImageEN/2024-04/Large/829b83be-23a9-41b8-8cc6-21f70b817d7c.gif)
AT-1002 NEW
Price | $10 | $6 | $2 |
Package | 1KG | 100KG | 1000KG |
Min. Order: | 1KG |
Supply Ability: | g-kg-tons, free sample is available |
Update Time: | 2024-04-28 |
Product Details
Product Name: AT-1002 | CAS No.: 835872-35-0 |
Min. Order: 1KG | Purity: 99% |
Supply Ability: g-kg-tons, free sample is available | Release date: 2024/04/28 |
Lead time: In stock | Packaging: bottle/drum/bucket/IBC, as request. |
Delivery: By sea, by air, by express | Origin: Manufacturer |
1. Product information
Name | (2S)-2-[[(2S)-2-[[2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoic acid |
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Synonym | More Synonyms |
Description | AT-1002, a 6-mer synthetic peptide[1], is a tight junction regulator and absorption enhancer[2]. |
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Related Catalog | Research Areas >> Metabolic Disease Signaling Pathways >> Cytoskeleton >> Gap Junction Protein |
In Vitro | AT-1002 a 6-mer synthetic peptide belongs to an emerging novel class of compounds that reversibly increase paracellular transport of molecules across the epithelial barrier. AT-1002 can undergo Cys-Cys dimerization[1]. Undifferentiated Caco-2 cells are treated with AT-1002 and viability is assessed by measuring cellular ATP content. Treatment with AT-1002 for up to 3 h does not affect cell viability at any concentration. In particular, the viability of Caco-2 cells is not affected by 5 mg/mL AT-1002. AT-1002 reduces cell viability after 24 h at concentrations of 2.5 mg/mL and higher. However, the cells remain viable after 24 h if the cells are washed after exposure to AT-1002 for 3 h indicating that AT-1002 does not irreversibly damage cells[2]. AT-1002 treatment results in 3-fold increase in phosphotyrosine content of zonula occludens-1 (ZO-1)[2]. |
References | [1]. Li M, et al. Structure-activity relationship studies of permeability modulating peptide AT-1002. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4584-6. [2]. Gopalakrishnan S, et al. Mechanism of action of ZOT-derived peptide AT-1002, a tight junction regulator and absorption enhancer. Int J Pharm. 2009 Jan 5;365(1-2):121-30. |
Molecular Formula | C32H53N9O7S |
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Molecular Weight | 707.88 |
Exact Mass | 707.37900 |
PSA | 326.97000 |
LogP | 5.07440 |
2. Packaging
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping
4. Contact information
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
- Since: 2023-02-10
- Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro