咪达普利拉
中文名称 | 咪达普利拉 |
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中文同义词 | 咪达普利拉;IMIDAPRILATE (6366A);米达普利杂质;IMIDAPRILAT|||6366A;咪达普利二酸 |
英文名称 | IMIDAPRILAT |
英文同义词 | IMIDAPRILAT;(4S)-3-{(2S)-2-[N-((1S)-1-Carboxy-3-phenylpropyl)amino]propionyl}-1-methyl-2-oxoimidazolidine-4-carboxylic Acid;Imidapril Diacid;(4S)-3-[(2S)-N-[(1S)-1-Carboxy-3-phenylpropyl]alanyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic acid;6366A;Imidaprilate;(4S)-3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid;4-Imidazolidinecarboxylic acid, 3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-, (4S)- |
CAS号 | 89371-44-8 |
分子式 | C18H23N3O6 |
分子量 | 377.39 |
EINECS号 | |
相关类别 | 杂质对照品;Intermediates & Fine Chemicals;Pharmaceuticals |
Mol文件 | 89371-44-8.mol |
结构式 |
咪达普利拉 性质
熔点 | 180-1820C |
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比旋光度 | D19 -88.4° (c = 1 in 5% NaHCO3) |
沸点 | 592.1±60.0 °C(Predicted) |
密度 | 1.356±0.06 g/cm3(Predicted) |
储存条件 | -20°C Freezer |
溶解度 | 可溶于酸性水溶液(轻微、加热、超声处理)、DMSO(轻微、加热) |
形态 | 固体 |
酸度系数(pKa) | 2.17±0.10(Predicted) |
颜色 | 白色至类白色 |
IC50: 2.6 nM (ACE)
Imidaprilate (6366A) is an active metabolite of 6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC 50 of 2.6 nM. Imidaprilate augments the bradykinin-induced contraction of guinea pig ileum, with AC 50 of 1.7 nM.
Imidaprilate (≥0.2 mg/kg) inhibits angiotensin I (AT-I)-induced pressor response. TA-6366 lowers the blood pressure in two-kidney one-clip renal hypertensive rats at 0.5-2 mg/kg via oral administration, and in spontaneously hypertensive rats (SHRs) at 2 to 10 mg/kg.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/11/08 | HY-109592 | 咪达普利拉 Imidaprilate | 89371-44-8 | 1mg | 6950元 |