|
|
| | Adenosine 5'-diphosphoribose sodium salt Basic information |
| Product Name: | Adenosine 5'-diphosphoribose sodium salt | | Synonyms: | ADENOSINE-5'-DIPHOSPHORIBOSE SODIUM SALT DIHYDRATE;adenosine 5'-diphosphoribose sodium;ADENOSINE-5'-DIPHOSPHORIBOSE SODIUM SALT 2-HYDRATE;ADENOSINE 5'-DIPHOSPHORIBOSE SODIUM SALT;[[5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXYOXOLAN-2-YL]METHOXY-HYDROXYPHOSPHORYL] (2,3,4-TRIHYDROXY-5-OXOPENTYL) HYDROGEN PHOSPHATE,SODIUM;Adenosine 5'-diphosphoribose sodium salt >=93%;adp-ribose;ADP ribose sodium | | CAS: | 68414-18-6 | | MF: | C15H22N5NaO14P2 | | MW: | 581.3 | | EINECS: | | | Product Categories: | | | Mol File: | 68414-18-6.mol |  |
| | Adenosine 5'-diphosphoribose sodium salt Chemical Properties |
| storage temp. | -20°C | | form | Solid | | color | White to light yellow | | Water Solubility | Water : 125 mg/mL (215.04 mM) | | InChIKey | MBPRZUBFEMLFGQ-UUIVKEFHSA-M | | SMILES | O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)C=O)O[C@H]1N1C=NC2C(=NC=NC1=2)N)O.[NaH] |&1:1,2,3,15,17,19,24,r| |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | Adenosine 5'-diphosphoribose sodium salt Usage And Synthesis |
| Description | Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. It is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator and can also enhance autophagy.
| | Uses | 5′-Deoxy-5′-(methylthio)adenosine has been used:
- to give a range of nicotinamide adenine dinucleotide (NADH)
- oxidation rates for the respiratory complex (CI/CIII/CIV)
- CI/alternative(AOX) pathway
- to measure poly(ADP-ribose) glycohydrolaseactivity
- poly(ADP-ribose) (PAR) binding competition assay
- oxidase?(AOX) pathway
- to measure poly(ADP-ribose) glycohydrolase activity
- poly(ADP-ribose) (PAR) binding competition assay
| | Biochem/physiol Actions | ADP-Ribose is used as the basic building block used as a substrate in the formation of poly(ADP-ribose) by members of the poly(ADP-ribose) polymerase (PARP) family. Poly(ADP-ribose) formation and degradation are an important components of DNA repair and apoptosis signaling. | | in vitro |
In mouse embryonic fibroblasts (MEFs), H2O2 treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca2+ elevation through extracellular Ca2+ influx and (or) lysosomal Ca2+ release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress.
TRPM2 channels are activated by binding Adenosine 5′-diphosphoribose (ADP ribose) to the intracellular NUDT9-homology (NUDT9-H) domain unique to TRPM2 and located at its C terminus. In addition to ADPR, intracellular Ca2+ is an essential coactivator: TRPM2 channels open only in the combined presence of both ligands.
|
| | Adenosine 5'-diphosphoribose sodium salt Preparation Products And Raw materials |
|