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Syntechem Co.,Ltd
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Product Name:(S)-2-aMino-4-(guanidinooxy)butanoic acid
CAS:543-38-4
Purity:97% Package:1g;5g;25g;100g;250g;1kg;5kg;10kg;25kg Remarks:we offer low price custom synthesis and contract manufacturing
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L-Canavanine manufacturers
- (L)-Canavanine
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- $1980.00 / 50mg
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2024-10-28
- CAS:543-38-4
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | L-Canavanine Basic information |
| Product Name: | L-Canavanine | | Synonyms: | L-Homoserine, O-(aminoiminomethyl)amino-;l-α-amino-γ-(guanidinooxy)-n-butyric acid;2-amino-4-(diaminomethylideneamino)oxy-butanoic acid;L-canavanine free base from jack beans*crystallin;BUTYRICACID,2-AMINO-4-(GUANIDINOOXY)-L-;(+)-O-(Guanidino)-L-homoserine;(S)-2-Amino-4-(guanidinooxy)butyric acid;2-amino-4-(guanidinooxy)butyricacid | | CAS: | 543-38-4 | | MF: | C5H12N4O3 | | MW: | 176.17 | | EINECS: | | | Product Categories: | | | Mol File: | 543-38-4.mol |  |
| | L-Canavanine Chemical Properties |
| Melting point | 184° | | alpha | D20 +7.9° (c = 3.2) | | Boiling point | 307.78°C (rough estimate) | | density | 1.3685 (rough estimate) | | refractive index | 1.7900 (estimate) | | storage temp. | 2-8°C | | solubility | H2O: <100 mg/mL | | form | powder | | pka | pK1: 2.50(+2);pK2: 6.60(+1);pK3: 9.25(0) (25°C) | | PH | 7.93 | | optical activity | +7.920 (H2O) |
| | L-Canavanine Usage And Synthesis |
| Uses | NO synthase inhibitor | | Definition |
ChEBI: L-canavanine is a non-proteinogenic L-alpha-amino acid that is L-homoserine substituted at oxygen with a guanidino (carbamimidamido) group. Although structurally related to L-arginine, it is non-proteinogenic. It has a role as a phytogenic insecticide and a plant metabolite. It is functionally related to a L-homoserine. It is a conjugate base of a L-canavanine(1+). It is a tautomer of a L-canavanine zwitterion.
| | Biochem/physiol Actions | L-Canavanine is a naturally occurring L-amino acid that interferes with L-arginine-utilizing enzymes due to its structural similarity. It is a selective inhibitor of inducible nitric oxide synthase (iNOS). Overproduction of NO by iNOS plays a crucial role in the pathophysiology of septic shock and chronic inflammation. | | Purification Methods | Crystallise S-canavanine from absolute EtOH or aqueous EtOH. [Tomiyama J Biol Chem 111 48 1935 gave pK9.25 (COOH), pK 7.4 (guanidinium), pK 11.5 (NH4+), Gulland & Morris J Chem Soc 763 1935,(±) Frankel et al. J Chem Soc 3127 1963, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2622-2628 1961, Beilstein 4 III 1636, 4 IV 3188.] |
| | L-Canavanine Preparation Products And Raw materials |
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