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SSR 69071

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Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:SSR 69071
CAS:344930-95-6
Package:1mg;78USD|5mg;297USD|10mg;575USD
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:SSR 69071
CAS:344930-95-6
Purity:>=98%(HPLC) Package:$229.9/10mg;Bulk package Remarks:98%(HPLC)
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:SSR 69071;2-[[6-Methoxy-4-(1-Methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]Methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyriMidin-4-one
CAS:344930-95-6
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Products Intro: Product Name:SSR 69071
CAS:344930-95-6
Purity:98% by HPLC Remarks:SSR 69071 is a potent and high affinity human leukocyte elastase (HLE) inhibitor (IC50 = 3.9 nM) that displays species-selectivity (Ki = 0.017, 1.70, 3.01, 58 and > 100 nM for human, mouse, rat, rabbi
Company Name: EMMX Biotechnology LLC  
Tel: 888-539-0666
Email: info@emmx.com
Products Intro: Product Name:SSR 69071
CAS:344930-95-6
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g

SSR 69071 manufacturers

  • SSR 69071
  • SSR 69071 pictures
  • $78.00 / 1mg
  • 2024-10-28
  • CAS:344930-95-6
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  • Supply Ability: 10g
SSR 69071 Basic information
Product Name:SSR 69071
Synonyms:SSR 69071;2-[[6-Methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyrimidin-4-one;4H-Pyrido[1,2-a]pyrimidin-4-one, 2-[[6-methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-
CAS:344930-95-6
MF:C27H32N4O7S
MW:556.63
EINECS:
Product Categories:
Mol File:344930-95-6.mol
SSR 69071 Structure
SSR 69071 Chemical Properties
storage temp. Store at +4°C
solubility Soluble in DMSO
form solid
color Off-white
Safety Information
MSDS Information
SSR 69071 Usage And Synthesis
DescriptionSSR 69071 is a potent inhibitor of neutrophil elastase (Ki = 0.0168 nM for the human enzyme). It is selective for human neutrophil elastase over rat, mouse, and rabbit elastases (Kis = 3, 1.8, 58 nM, respectively). It inhibits human neutrophil elastase ex vivo in mouse bronchoalveolar lavage (BAL) fluid (ED50 = 10.5 mg/kg, p.o.). In vivo, SSR 69071 (2.8 mg/kg, p.o.) reduces acute lung hemorrhage induced by human neutrophil elastase in mice. It reduces carrageenan- and human neutrophil elastase-induced paw edema in rats (ED30s = 2.2 and 2.7 mg/kg, respectively). SSR 69071 also reduces cardiac infarct size when administered prior to ischemia or reperfusion in a rabbit model of ischemia-reperfusion injury.
UsesSSR 69071 is a novel and orally active elastase inhibitor.
DefinitionChEBI: 6-methoxy-1,1-dioxo-2-[[4-oxo-9-[2-(1-piperidinyl)ethoxy]-2-pyrido[1,2-a]pyrimidinyl]oxymethyl]-4-propan-2-yl-1,2-benzothiazol-3-one is a pyridopyrimidine.
Biological ActivityOrally active, high affinity and potent inhibitor of human leukocyte elastase (HLE) (IC 50 = 3.9 nM). Displays species-selectivity (K i values are 0.017, 1.70, 3.01, 58 and > 100 nM? for human, mouse, rat, rabbit and porcine elastase respectively). In vivo, inhibits HLE-induced lung hemorrhage in mice (ID 50 = 2.8 mg/kg) and reduces infarct size in an acute model of coronary ischemia-reperfusion injury.
storageStore at +4°C
SSR 69071 Preparation Products And Raw materials
Tag:SSR 69071(344930-95-6) Related Product Information
SSR 69071 N-HYDROXYMETHYLSACCHARIN 1,2-BENZISOTHIAZOL-3(2H)-ONE, 6-METHOXY, 1,1-DIOXIDE