| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:SSR 69071;2-[[6-Methoxy-4-(1-Methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]Methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyriMidin-4-one
CAS:344930-95-6
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:SSR 69071
CAS:344930-95-6
Purity:98% by HPLC Remarks:SSR 69071 is a potent and high affinity human leukocyte elastase (HLE) inhibitor (IC50 = 3.9 nM) that displays species-selectivity (Ki = 0.017, 1.70, 3.01, 58 and > 100 nM for human, mouse, rat, rabbi
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| Company Name: |
EMMX Biotechnology LLC
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| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:SSR 69071
CAS:344930-95-6
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| | SSR 69071 Basic information |
| Product Name: | SSR 69071 | | Synonyms: | SSR 69071;2-[[6-Methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyrimidin-4-one;4H-Pyrido[1,2-a]pyrimidin-4-one, 2-[[6-methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]- | | CAS: | 344930-95-6 | | MF: | C27H32N4O7S | | MW: | 556.63 | | EINECS: | | | Product Categories: | | | Mol File: | 344930-95-6.mol |  |
| | SSR 69071 Chemical Properties |
| storage temp. | Store at +4°C | | solubility | Soluble in DMSO | | form | solid | | color | Off-white |
| | SSR 69071 Usage And Synthesis |
| Description | SSR 69071 is a potent inhibitor of neutrophil elastase (Ki = 0.0168 nM for the human enzyme). It is selective for human neutrophil elastase over rat, mouse, and rabbit elastases (Kis = 3, 1.8, 58 nM, respectively). It inhibits human neutrophil elastase ex vivo in mouse bronchoalveolar lavage (BAL) fluid (ED50 = 10.5 mg/kg, p.o.). In vivo, SSR 69071 (2.8 mg/kg, p.o.) reduces acute lung hemorrhage induced by human neutrophil elastase in mice. It reduces carrageenan- and human neutrophil elastase-induced paw edema in rats (ED30s = 2.2 and 2.7 mg/kg, respectively). SSR 69071 also reduces cardiac infarct size when administered prior to ischemia or reperfusion in a rabbit model of ischemia-reperfusion injury. | | Uses | SSR 69071 is a novel and orally active elastase inhibitor. | | Definition | ChEBI: 6-methoxy-1,1-dioxo-2-[[4-oxo-9-[2-(1-piperidinyl)ethoxy]-2-pyrido[1,2-a]pyrimidinyl]oxymethyl]-4-propan-2-yl-1,2-benzothiazol-3-one is a pyridopyrimidine. | | Biological Activity | Orally active, high affinity and potent inhibitor of human leukocyte elastase (HLE) (IC 50 = 3.9 nM). Displays species-selectivity (K i values are 0.017, 1.70, 3.01, 58 and > 100 nM? for human, mouse, rat, rabbit and porcine elastase respectively). In vivo, inhibits HLE-induced lung hemorrhage in mice (ID 50 = 2.8 mg/kg) and reduces infarct size in an acute model of coronary ischemia-reperfusion injury. | | storage | Store at +4°C |
| | SSR 69071 Preparation Products And Raw materials |
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