- Falnidamol
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- $58.00 / 5mg
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2024-11-19
- CAS:196612-93-8
- Min. Order:
- Purity: 96.46%
- Supply Ability: 10g
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| | BIBX 1382 DIHYDROCHLORIDE Basic information |
| Product Name: | BIBX 1382 DIHYDROCHLORIDE | | Synonyms: | BIBX 1382 DIHYDROCHLORIDE;8-(3-Chloro-4-fluoroanilino)-2-((1-methyl-4-piperidyl)amino)pyrimido(5,4-D)pyrimidine;Falnidamol;Falnidamol [inn];Pyrimido(5,4-D)pyrimidine-2,8-diamine, N8-(3-chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-;Unii-0mu316797d;N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diaminedihydrochloride;Falnid | | CAS: | 196612-93-8 | | MF: | C18H19ClFN7 | | MW: | 387.84 | | EINECS: | | | Product Categories: | | | Mol File: | 196612-93-8.mol |  |
| | BIBX 1382 DIHYDROCHLORIDE Chemical Properties |
| Melting point | >217°C (dec.) | | Boiling point | 552.0±60.0 °C(Predicted) | | density | 1.427 | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 8?+-.0.10(Predicted) | | form | Solid | | color | Pale Yellow to Yellow | | Water Solubility | water: 1mg/mL
DMSO: 25mg/mL |
| | BIBX 1382 DIHYDROCHLORIDE Usage And Synthesis |
| Uses | Falnidamol is a novel ErbB receptor kinase inhibitor that is more potent at inhibiting signaling induced by TGF-α than that induced by neuregulin1-β1 or anti-ErbB2 agonist antibodies. | | Uses | BIBX 1382 Dihydrochloride, is a potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). | | Definition | ChEBI: N4-(3-chloro-4-fluorophenyl)-N6-(1-methyl-4-piperidinyl)pyrimido[5,4-d]pyrimidine-4,6-diamine is a substituted aniline. | | Biological Activity | Potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 3 nM). Displays > 1000-fold lower potency against ErbB2 (IC 50 = 3.4 μ M) and a range of other related tyrosine kinases (IC 50 > 10 μ M). Oral administration inhibits growth of established human xenografts in athymic mice. | | references | 1. f. f. solca, a. baum, e. langkopf, g. dahmann, k. h. heider, f. himmelsbach and j. c. van meel, j pharmacol exp ther 2004, 311, 502-509. |
| | BIBX 1382 DIHYDROCHLORIDE Preparation Products And Raw materials |
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