|
|
| | 1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone Basic information |
| Product Name: | 1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone | | Synonyms: | 5-Acetyl-2-(trifluoromethyl)pyridine;1-(6-(trifluoroMethyl)pyridine-3-yl)ethanone;[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE;1-(6-(Trifluoromethyl);1-(6-(Trifluoromethyl)pyridin-3-yl);1-[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE;ETHANONE, 1-[6-(TRIFLUOROMETHYL)-3-PYRIDINYL]-;1-[6-(Trifluoromethyl)pyridin-3-yl]ethan-1-one | | CAS: | 358780-14-0 | | MF: | C8H6F3NO | | MW: | 189.13 | | EINECS: | | | Product Categories: | | | Mol File: | 358780-14-0.mol |  |
| | 1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone Chemical Properties |
| Boiling point | 233.7±40.0 °C(Predicted) | | density | 1.280±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | -1.24±0.22(Predicted) | | InChI | InChI=1S/C8H6F3NO/c1-5(13)6-2-3-7(12-4-6)8(9,10)11/h2-4H,1H3 | | InChIKey | NAUKVLRFGMDIAN-UHFFFAOYSA-N | | SMILES | C(=O)(C1=CC=C(C(F)(F)F)N=C1)C |
| | 1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone Usage And Synthesis |
| Uses | 1-(6-(Trifluoromethyl)pyridin-3-yl)ethanone can be used as novel GPR119 agonists. | | Synthesis | To a solution of 2-trifluoromethyl-5-bromopyridine (5.0 g, 22 mmol) in Et2O (50 mL) was added sec-BuLi (0.91 M in cyclohexane, 24 mL, 22 mmol) at -78 °C. After 10 minutes of stirring, N,N-dimethylaminoacetamide (2.3 mL, 24 mmol) dissolved in Et2O (10 mL) was added drop wise. Stirring was continued at -78 °C for 1 h and then at rt over night. The reaction mixture was poured into water (100 mL) and the water phase was extracted with Et2O (3×100 mL). Combined organics were washed with water and brine and dried (MgSO4). After careful evaporation of the solvent, the crude was purified by column chromotography (SiO2, pentane/ether 9/1) to give 1-(6-(Trifluoromethyl)pyridin-3-yl)ethanone (2.3 g, 12 mmol, 54%) as a light yellow solid. 1H NMR (CDCl3) δ 9.26 (br s, 1H) 8.43 (br d, J=5.6 Hz, 1H) 7.83 (br d, J=7.2 Hz, 1H) 2.71 (s, 3H).
 |
| | 1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone Preparation Products And Raw materials |
|