| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:AMN082 Dihydrochloride
CAS:83027-13-8
Purity:>99% Package:10mg, 50mg
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:AMN 082 dihydrochloride;N,N'-Bis(diphenylMethyl)-1,2-ethanediaMinedihydrochloride
CAS:83027-13-8
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| | AMN082 DIHYDROCHLORIDE Basic information |
| Product Name: | AMN082 DIHYDROCHLORIDE | | Synonyms: | AMN 082;N,N'-DIBENZHYDRYLETHANE-1,2-DIAMINE DIHYDROCHLORIDE;N,N'-BIS(DIPHENYLMETHYL)-1,2-ETHANEDIAMINE DIHYDROCHLORIDE;AMN082 DIHYDROCHLORIDE;N,N'-Bis(diphenylmethyl)-1,2-ethandiamine dihydrochloride;N,N'-bis(diphenylMethyl)ethylenediaMine;AMN 082 dihydrochlor;AMN082 free base | | CAS: | 83027-13-8 | | MF: | C28H28N2 | | MW: | 392.54 | | EINECS: | | | Product Categories: | Glutamate;Glutamate receptor | | Mol File: | 83027-13-8.mol |  |
| | AMN082 DIHYDROCHLORIDE Chemical Properties |
| Melting point | 105.5 °C | | Boiling point | 533.7±45.0 °C(Predicted) | | density | 1.086±0.06 g/cm3(Predicted) | | storage temp. | Desiccate at +4°C | | solubility | DMSO : 12.5 mg/mL (31.84 mM; ultrasonic and warming and heat to 60°C) | | pka | 8.38±0.29(Predicted) | | form | Solid | | color | White to off-white |
| | AMN082 DIHYDROCHLORIDE Usage And Synthesis |
| Uses | AMN082 dihydrochloride is a selective agonist at mGluR-7. | | Definition | ChEBI: N,N'-bis(diphenylmethyl)ethane-1,2-diamine is a diamine that is ethane-1,2-diamine in which both amino groups are substituted by diphenylmethyl groups. It is an allosteric agonist of the metabotropic glutamate receptor 7 (mGluR7). It has a role as a metabotropic glutamate receptor agonist and a neuroprotective agent. It is a diarylmethane, a secondary amino compound, a diamine and a member of benzenes. It is a conjugate base of a N,N'-bis(diphenylmethyl)ethane-1,2-diamine(2+). | | Biological Activity | The first selective mGlu 7 agonist. Potently inhibits cAMP accumulation and stimulates GTP γ S binding in recombinant cells and on membranes expressing mGlu 7 (EC 50 = 64-290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 μ M. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats. |
| | AMN082 DIHYDROCHLORIDE Preparation Products And Raw materials |
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