| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Apigenin-d5 (Major)
CAS:263711-74-6
Package:10Mg,1Mg
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| | Apigenin-D5 Basic information |
| Product Name: | Apigenin-D5 | | Synonyms: | Apigenin-D5;[3,6,8,35d5]-Apigenin;4',5,7-Trihydroxyflavone-d5;5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d5;Pelargidenon 1449-d5;Apigenin-d5 (Major);3,6,8-trideuterio-2-(3,5-dideuterio-4-hydroxyphenyl)-5,7-dihydroxychromen-4-one;4H-1-Benzopyran-4-one-3,6,8-d3, 5,7-dihydroxy-2-(4-hydroxyphenyl-3,5-d2)- | | CAS: | 263711-74-6 | | MF: | C15H5D5O5 | | MW: | 0 | | EINECS: | | | Product Categories: | Isotope Labelled Compounds;Inhibitors;Isotope Labeled Compounds | | Mol File: | 263711-74-6.mol |  |
| | Apigenin-D5 Chemical Properties |
| Melting point | 345-350°C | | storage temp. | -20°C Freezer | | solubility | DMSO (Slightly), Ethanol (Slightly, Heated), Methanol (Slightly) | | form | Solid | | color | Pale Yellow to Yellow |
| | Apigenin-D5 Usage And Synthesis |
| Description | Apigenin-d5 is an internal standard for the quantificaiton of apigenin by GC- or LC-MS. Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase 2 (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC50 value of 30 μM to improve renal function in a rat model of glomerulonephritis. CK2 inhibition by 20 μM apigenin decreases the degradation of IκBα and down-regulates NF-κB levels in WEHI-231 cells. Apigenin, at 5 μM, is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1. | | Chemical Properties | Pale Yellow Crystalline Solid | | Uses | The labelled aglucon of apiin and of apigenin-7-glucoside |
| | Apigenin-D5 Preparation Products And Raw materials |
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