Company Name: |
TargetMol Chemicals Inc.
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Tel: |
15002134094 |
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marketing@targetmol.cn |
Products Intro: |
Product Name:Chlorozotocin CAS:54749-90-5 Purity:0 Package:25mg/RMB 10600;100mg/RMB 17500;50mg/RMB 13800
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| Chlorozotocin Basic information |
Product Name: | Chlorozotocin | Synonyms: | CZT;DCNU;NCS-178248;NCS-D-254157;Chlorozotocin;2-(3-(2-CHLOROETHYL)-3-NITROSOUREIDO)-D-GLUCOPYRANOSE;CHLZ;D-Glucose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy- | CAS: | 54749-90-5 | MF: | C9H16ClN3O7 | MW: | 313.69 | EINECS: | | Product Categories: | | Mol File: | 54749-90-5.mol | |
| Chlorozotocin Chemical Properties |
Melting point | 147-148° (dec with the evolution of gas); mp 140-141° (dec) | Boiling point | 119.3°C (rough estimate) | density | 1.6475 (rough estimate) | refractive index | 1.6000 (estimate) | pka | 9.08±0.46(Predicted) | IARC | 2A (Vol. 50) 1990 | EPA Substance Registry System | Chlorozotocin (54749-90-5) |
| Chlorozotocin Usage And Synthesis |
Chemical Properties | Chlorozotocin is a nitrosourea compound that exists as ivory-coloredcrystals at room temperature. It is soluble in water and is stable in solution at room temperature for up to 3 hours and under refrigeration for 24 hours. The powder form of chlorozotocin is stable under refrigeration for two years. The spontaneous, nonenzymatic degradation of chlorozotocin results in formation of DNA-alkylating and protein-carbamoylating moieties (Chabner et al. 2001). | Uses | Chlorozotocin is a cytostatic agent that has been used to treat melanoma and multiple myeloma and cancer of the stomach, large intestine, pancreas, and lung (IARC 1990). | Definition | ChEBI: Chlorozotocin is an amino sugar. | Safety Profile | Confirmed carcinogen
with experimental carcinogenic and
tumorigenic data. Poison by subcutaneous,
intravenous, and intraperitoneal routes.
Human systemic effects by intravenous
route: anorexia, leukopenia, nausea or
vomiting, thrombocytopenia. Mutation data
reported. When heated to decomposition it
emits very toxic fumes of Cland NOx. See
also NITROSAMINES. | Carcinogenicity | Chlorozotocin is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals and because it is a member of a well-defined, structurally related class of substances listed in the Report on Carcinogensas either known to be a human carcinogen or reasonably anticipated to be a human carcinogen. |
| Chlorozotocin Preparation Products And Raw materials |
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