| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:(-)-Neplanocin A
CAS:72877-50-0
Purity:>98% Package:1mg;10mg;50mg;100mg;
|
| Company Name: |
Changzhou Xuanye Technology Co., Ltd
|
| Tel: |
15195022192 |
| Email: |
279776773@qq.com |
| Products Intro: |
Product Name:neplanocin A
CAS:72877-50-0
Purity:97 Package:1g,5g,10g,25g,50g 500 g ,1 kg.5 kg
|
| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:(-)-Neplanocin A
CAS:72877-50-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
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| | neplanocin A Basic information |
| Product Name: | neplanocin A | | Synonyms: | neplanocin A;A-11079B16;Antibiotic A-11079B16;Neoplanocin A;3-Neplanocin A;()-Neplanocin A Exclusive;3-Cyclopentene-1,2-diol, 5-(6-amino-9H-purin-9-yl)-3-(hydroxymethyl)-, (1S,2R,5R)-;(?)-Neplanocin A | | CAS: | 72877-50-0 | | MF: | C11H13N5O3 | | MW: | 263.25 | | EINECS: | | | Product Categories: | | | Mol File: | 72877-50-0.mol |  |
| | neplanocin A Chemical Properties |
| Melting point | 214-216 °C (decomp) | | Boiling point | 632.6±65.0 °C(Predicted) | | density | 1.91±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 0.2 mg/ml; DMSO: 3 mg/ml; PBS (pH 7.2): 0.3 mg/ml | | form | A crystalline solid | | pka | 13.43±0.70(Predicted) |
| | neplanocin A Usage And Synthesis |
| Description | S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine. The inhibition of SAH hydrolase causes the intracellular accumulation of SAH, elevating the ratio of SAH to S-adenosylmethionine (SAM) and inhibiting SAM-dependent methyltransferase. (−)-Neplanocin A potently and irreversibly inactivates SAH hydrolase (Ki = 8.39 nM). It has antitumor activity against mouse leukemia L1210 cells and broad-spectrum antiviral activity. Neplanocin A is more potent against vesicular stomatitis than the reversible SAH hydrolase inhibitor 3-deazaneplanocin (ID50 = 0.07 and 0.3 μg/ml, respectively). |
| | neplanocin A Preparation Products And Raw materials |
| Raw materials | Imidodicarbonic acid, 2-[9-[(3aS,4R,6aR)-6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3a,6a-dihydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]-9H-purin-6-yl]-, 1,3-bis(1,1-dimethylethyl) ester |
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