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| | 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Basic information |
| Product Name: | 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one | | Synonyms: | Ivabradine Impurity 13;1,3-Dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one;7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one;7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one;2H-3-Benzazepin-2-one,1,3-dihydro-7,8-diMethoxy-;1,3-Dihydro-7,8-dimethoxybenzo[d]azepin-2-one;7,8-diMethoxy-2,3-dihydro-1H-3-benzazepin-2-one;7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one | | CAS: | 73942-87-7 | | MF: | C12H13NO3 | | MW: | 219.24 | | EINECS: | 456-160-0 | | Product Categories: | Aromatics;Heterocycles;Intermediates | | Mol File: | 73942-87-7.mol |  |
| | 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Chemical Properties |
| Melting point | 244.0 to 248.0 °C | | Boiling point | 455.8±45.0 °C(Predicted) | | density | 1.167 | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), DMSO (Slightly) | | form | Solid | | pka | 13.29±0.20(Predicted) | | color | Off-White to Pale Beige | | LogP | 1.23 at 23℃ and pH6.47 | | Surface tension | 71mN/m at 36.9mg/L and 19℃ | | CAS DataBase Reference | 73942-87-7(CAS DataBase Reference) |
| | 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Usage And Synthesis |
| Uses | 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is a substituted benzazepinonee derivative used in the preparation of bradycardic agents as well as isoform-selective f-current blockers. | | Application | 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is used in the industrial preparation of pharmaceuticals and can be reacted with trifluoroacetic acid to form 3,4-dimethoxyphenylacetic acid. | | Definition | ChEBI: 7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one is a benzazepine. | | Synthesis | 1.Charge 142.0 g of N-(2,2-dimethoxyethyl)-2-(3,4-dimethoxyphenyl) acetamide, 710 ml of glacial acetic acid and 710 ml of conc. hydrochloric acid in a 3.0 L round bottom flask equipped with mechanical stirrer and thermometer pocket at 25°C.
2.Stir the mixture for 17 hours at 25°C.
3.Monitor the reaction by HPLC (starting material should be less than 4.0%).
4.Pour the reaction mixture on 3.0 kg of crushed ice, if HPLC complies.
5.Stir the mixture for 30 minutes and filter the solid material.
6.Wash the mixture with 1 L of water, suck dry and unload the material.
7.Dry the 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one under vacuum at 55-60°C till the LOD comes to below 0.5%.
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| | 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Preparation Products And Raw materials |
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