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Tolperisone hydrochloride

Tolperisone hydrochloride Suppliers list
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Products Intro: Product Name:Tolperisone Hydrochloride
CAS:3644-61-9
Purity:99% Package:1KG;1.00;USD
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Products Intro: Product Name:Tolperisone Hydrochloride
CAS:3644-61-9
Purity:99% Package:25KG
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Products Intro: Product Name:Tolperisone hydrochloride
CAS:3644-61-9
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Products Intro: Product Name:Tolperisone Hydrochloride
CAS:3644-61-9
Purity:More Than 99% Package:1g
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Products Intro: Product Name:Tolperisone Hydrochloride
CAS:3644-61-9
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg

Tolperisone hydrochloride manufacturers

Tolperisone hydrochloride Basic information
Product Name:Tolperisone hydrochloride
Synonyms:1-piperidino-2-methyl-3-(p-tolyl)-3-propanonehydrochloride;LABOTEST-BB LT00772344;2-Methyl-1-(4-methylphenyl)-3-(1-piperidyl)propan-1-one hydrochloride;Tolperizone hydrochloride;4'-METHYL-2-(1-PIPERIDINYLMETHYL)-PROPIOPHENONE HCL;4'-methyl-2-(1-piperidinylmethyl)-propiophenone hydrochloride;2,4'-DIMETHYL-3-PIPERIDINOPROPIOPHENONE HYDROCHLORIDE;2,4'-dimethyl-3-piperidinopropiophenone monohydrochloride
CAS:3644-61-9
MF:C16H24ClNO
MW:281.82
EINECS:222-876-5
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:3644-61-9.mol
Tolperisone hydrochloride Structure
Tolperisone hydrochloride Chemical Properties
Melting point 181-183°C
storage temp. room temp
solubility H2O: >20mg/mL
form solid
color white
PHpH(50g/l, 25℃) : 4.5~5.5
Water Solubility almost transparency
Merck 14,9522
CAS DataBase Reference3644-61-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 20/21/22-52/53-36/37/38
Safety Statements 26-36-45-61-36/37-37/39
WGK Germany 3
RTECS UH1575500
ToxicityLD50 s.c. in mice: 620 mg/kg (Porszasz, 1961)
MSDS Information
Tolperisone hydrochloride Usage And Synthesis
Chemical PropertiesWhite Solid
OriginatorTolperisone hydrochloride,Shanghai Abochem Chemical Co.
UsesTolperisone hydrochloride can be used as a muscle relaxant.
DefinitionChEBI: Tolperisone hydrochloride is an aromatic ketone.
Manufacturing ProcessTo 1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanol in chloroform was added an excess of thionyl chloride and the reaction mixture refluxed until completed. It was then taken to dryness under reduced pressure and the residue crystallized by dissolving in hot alcohol and diluting with ethyl acetate. An aqueous solution of the obtained N-[3-chloro-3-(p-tolyl)propyl]piperidine hydrochloride was hydrogenated at 3 atmospheres in the presence of buffered palladium-on-charcoal catalyst. 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone was purified by distilling the base (boiling point 106-107°C/1 mm) and reconverting to the hydrochloride, melting point 216-217°C.
Therapeutic FunctionMuscle relaxant, Vasodilator
Biochem/physiol ActionsTolperisone is derived from piperidine and possesses membrane stabilizing action. It helps in reducing the effect of spasticities associated with the nervous and muscular system. It exhibits muscle relaxant action through attenuating voltage-gated sodium channels in the brain stem.
Tolperisone hydrochloride Preparation Products And Raw materials
Raw materialsPiperidine-->4'-Methylpropiophenone-->Paraformaldehyde
Tag:Tolperisone hydrochloride(3644-61-9) Related Product Information
M-METHYLPROPIOPHENONE Tolperisone Impurity A Tolperisone Impurity B Paroxetine hydrochloride Tolperisone Impurity C ETHYL-O-TOLYL KETONE 4'-Methylacetophenone 4'-Methylpropiophenone 1-(4-Ethylphenyl)-2-methyl-2-propen-1-one 1-(4-Ethylphenyl)-3-(piperidin-1-yl)propan-1-one hydrochloride 2-methyl-1-phenyl-3-(1-piperidyl)propan-1-one 1-Propanone, 1-(2-ethylphenyl)-2-methyl-3-(1-piperidinyl)-, hydrochloride (1:1) Eperisone Impurity 6(Hydrochloride) 3-METHYLAMINO-1-PHENYLACETONE HYDROCHLORIDE Eperisone hydrochloride 3-(diethylamino)propiophenone Tolperisone hydrochloride Tolperisone