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| | SC 57461A Basic information |
| | SC 57461A Chemical Properties |
| Melting point | 163-165°C | | storage temp. | Desiccate at +4°C | | solubility | DMSO: >5mg/mL | | form | powder | | color | white to off-white |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 |
| | SC 57461A Usage And Synthesis |
| Description | Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro. SC-57461A is a potent, orally active inhibitor of LTA4 hydrolase that blocks ionophore-stimulated LTB4 synthesis in whole blood (IC50 = 49 nM). It blocks both the hydrolase and aminopeptidase activity in vitro. SC-57461A is without effect against other enzymes of the arachidonic acid cascade, including 5-lipoxygenase, LTC4 synthase, COX-1, and COX-2. In a rat model of ionophore-induced peritoneal eicosanoid production, SC-57461A inhibits LTB4 biosynthesis without affecting LTC4 or 6-keto prostaglandin F1α production . Oral or topical pretreatment with SC-57461A before challenge with arachidonic acid blocks ear edema in mice. | | Chemical Properties | White Solid | | Uses | A potent and selective orally active leukotriene A4 hydrolase inhibitor. | | Uses | SC 57461A is a potent and selective inhibitor of LTA4. | | Biological Activity | Potent and selective inhibitor of LTA 4 hydrolase. Does not inhibit other enzymes of the arachidonic acid cascade including COX-1, COX-2, LTC 4 synthase and 5-lipoxygenase. Potently inhibits LTB 4 production in whole blood (IC 50 = 49 nM). Orally active. |
| | SC 57461A Preparation Products And Raw materials |
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