| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:ONO 4817;N-[(1S,3S)-1-[(EthoxyMethoxy)Methyl]-4-(hydroxyaMino)-3-Methyl-4-oxobutyl]-4-phenoxybenzaMide
CAS:223472-31-9
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| | N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE Basic information |
| | N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE Chemical Properties |
| density | 1.192±0.06 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | <20.82mg/ml in ethanol; <41.65mg/ml in DMSO | | form | solid | | pka | 9.55±0.40(Predicted) | | color | Off-white |
| | N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE Usage And Synthesis |
| Uses | MMP Inhibitor V is a broad-spectrum inhibitor of matrix metalloproteinase (MMPs). | | Biological Activity | Broad spectrum MMP inhibitor; K i values are 0.45, 0.73, 1.1, 1.1, 2.1, 42 and 2500 nM for MMP-12, MMP-2, MMP-8, MMP-13, MMP-9, MMP-3 and MMP-7 respectively and IC 50 = 1600 nM for MMP-1). Displays no activity at other proteases up to a concentration of 100 μ M. Exhibits antiangiogenic and anti-invasive properties on lung metastasis of murine renal cell carcinoma. | | references | [1]. okamoto, y., et al., a matrix metalloproteinase inhibitor, ono-4817, suppresses the development of aortic intimal hyperplasia in experimental hyperlipidemic rabbit. int heart j, 2007. 48(3): p. 369-78.
[2]. shiraga, m., et al., organ heterogeneity of host-derived matrix metalloproteinase expression and its involvement in multiple-organ metastasis by lung cancer cell lines. cancer res, 2002. 62(20): p. 5967-73.
[3]. ro, y., et al., inhibitory effects of matrix metalloproteinase inhibitor ono-4817 on morphological alterations in chlorhexidine gluconate-induced peritoneal sclerosis rats. nephrol dial transplant, 2007. 22(10): p. 2838-48. |
| | N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE Preparation Products And Raw materials |
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