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BOC Sciences
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1-631-485-4226; 16314854226 |
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Product Name:Vialinin A
CAS:858134-23-3
Purity:98% by HPLC Remarks:Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity (IC50 = 1.5, 5.9 and 22.3 μM, respectively), displayin
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| Company Name: |
Shanghai Aladdin Bio-Chem Technology Co.,LTD
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400-400-6206333 18521732826 |
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| Products Intro: |
Product Name:Vialinin A
CAS:858134-23-3
Purity:95% Package:1mg/RMB 1599.90;10mg/RMB 4699.00;25mg/RMB 9999.00
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| | TERRESTRIN A Basic information |
| Product Name: | TERRESTRIN A | | Synonyms: | TERRESTRIN A;VIALININ A;1,1'-(4,4'',5',6'-Tetrahydroxy[1,1':4',1''-terphenyl]-2',3'-diyl) benzeneacetic acid ester;NOJUKCRPSUMHQQ-UHFFFAOYSA-N;Benzeneacetic acid, 1,1'-(4,4'',5',6'-tetrahydroxy[1,1':4',1''-terphenyl]-2',3'-diyl) ester | | CAS: | 858134-23-3 | | MF: | C34H26O8 | | MW: | 562.57 | | EINECS: | | | Product Categories: | | | Mol File: | 858134-23-3.mol |  |
| | TERRESTRIN A Chemical Properties |
| Melting point | 220-223 °C | | Boiling point | 846.9±65.0 °C(Predicted) | | density | 1.370±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | crystalline solid | | pka | 7.81±0.15(Predicted) | | color | Off-white to light brown |
| | TERRESTRIN A Usage And Synthesis |
| Uses | Vialinin A is a Potent Inhibitor of TNF-α production. Vialinin A is a potent antioxidant. | | Biological Activity | vialinin a is a potent inhibitor of ubiquitin-specific peptidases with ic50 values of 1.5, 5.9 and 22.3 μm for ubiquitin-specific peptidase 4 (usp4), usp5/isopeptidase t (isot) and uch-l1 deubiquitinating enzyme (dub), respectively [1].ubiquitin-specific peptidases (usps) are a series of proteases that deubiquitinate target proteins. the dynamic modification of a protein with ubiquitin can modify its function, localization and fate in the cell. ubiquitin hydrolase plays an important role in immunology and infection [2].in rbl-2h3 cells, vialinin a inhibited tnf-ɑ production and release and inhibited usp5 enzymatic activity. in usp5 sirna-knockdown rbl-2h3 cells, vialinin a inhibited tnf-ɑ production and release in a dose dependent way. also, the mrna expression of tnf-ɑ was decreased significantly [2]. in rbl-2h3 cells, vialinin a inhibited tnf-ɑ production with ic50 value of 0.09 nm. also, it inhibited the release of interleukin 4, β-hexosaminidase and monocyte chemotactic protein 1, which suggested vialinin a had anti-allergic activities [3]. | | references | [1]. okada k, ye yq, taniguchi k, et al. vialinin a is a ubiquitin-specific peptidase inhibitor. bioorg med chem lett, 2013, 23(15): 4328-4331.
[2]. yoshioka y, ye yq, okada k, et al. ubiquitin-specific peptidase 5, a target molecule of vialinin a, is a key molecule of tnf-α production in rbl-2h3 cells. plos one, 2013, 8(12): e80931.
[3]. onose j, xie c, ye yq, et al. vialinin a, a novel potent inhibitor of tnf-alpha production from rbl-2h3 cells. biol pharm bull, 2008, 31(5): 831-833. |
| | TERRESTRIN A Preparation Products And Raw materials |
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