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| | PD 153035 HYDROCHLORIDE Basic information |
| Product Name: | PD 153035 HYDROCHLORIDE | | Synonyms: | PD 153035 HYDROCHLORIDE;PD153035HCl;4-(3-Bromphenylamino)-6,7-bis(methoxy)quinazoline;4-(3-Bromphenylamino)-6,7-dimethylquinazoline;4-Quinazolinamine, N-(3-bromphenyl)-6,7-dimethoxy-;Zinc00600292;4-(3-Bromo-benzyl)-6,7-dimethoxy-quinazoline;N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine | | CAS: | 153436-54-5 | | MF: | C16H14BrN3O2 | | MW: | 360.21 | | EINECS: | | | Product Categories: | Inhibitors;Inhibitor | | Mol File: | 153436-54-5.mol |  |
| | PD 153035 HYDROCHLORIDE Chemical Properties |
| Melting point | 189-190 °C | | Boiling point | 472.1±45.0 °C(Predicted) | | density | 1.499±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | Soluble in DMSO (up to 5 mg/ml). | | pka | 5.55±0.30(Predicted) | | form | White to off-white solid. | | color | White or off-white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| | PD 153035 HYDROCHLORIDE Usage And Synthesis |
| Description | AG-1517 HCl (153436-54-5) is an ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFR), with an IC50 of 25 pM. Inhibits other tyrosine kinases at micromolar or higher concentrations. It selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation.1?Inhibits the growth of a number of cancer cell lines.2?AG-1517 HCl is an extremely useful tool for exploring EGF-mediated cellular signaling.3 | | Chemical Properties | Yellowish solid | | Uses | PD 153035 is an extremely potent and specific inhibitor of EGFR tyrosine kinase activity. | | Uses | PD153035 is an inhibitor of EGFR, competitive with ATP. EGF Receptor: IC50 = 25 pM (Ki = 6 pM). | | Definition | ChEBI: A member of the class of quinazolines carrying a 3-bromophenylamino substituent at position 4 and two methoxy substituents at positions 6 and 7. | | Biological Activity | An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC 50 of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations. | | target | EGFR | | References | 1) Fry et al. (1994), A specific inhibitor of the epidermal growth factor receptor tyrosine kinase; Science, 265 1093
2) Bos et al. (1997), PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner; Clin. Cancer Res., 3 2099
3) Tetreault et al. (2008), Specific signaling cascades involved in cell spreading during healing of micro-wounded gastric epithelial monolayers; J. Cell. Biochem., 105 1240 |
| | PD 153035 HYDROCHLORIDE Preparation Products And Raw materials |
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