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Hydromorphone hydrochloride

Hydromorphone hydrochloride Basic information
Product Name:Hydromorphone hydrochloride
Synonyms:morphinan-6-one,4,5-alpha-epoxy-3-hydroxy-17-methyl-,hydrochloride,(5’-alpha;hydromorphone hydrochloride--dea*schedule ii item;HYDROMORPHONE HYDROCHLORIDE METHANOL*SOL UTION;HYDROMORPHONE HYDROCHLORIDE OPIATE ANALG ESIC;(5α)-4,5-epoxy-3-hydroxy-17-methyl-morphinan-6-one hydrochloride;hydromorphone hydrochloride solution;HYDROMORPHONEHYDROCHLORIDE,USP;Hydromorphine hydrochloride
CAS:71-68-1
MF:C17H20ClNO3
MW:321.8
EINECS:200-762-6
Product Categories:Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:71-68-1.mol
Hydromorphone hydrochloride Structure
Hydromorphone hydrochloride Chemical Properties
Melting point >280°C (dec.)
alpha D25 -133°
density 1.1451 (rough estimate)
refractive index 1.6470 (estimate)
storage temp. 2-8°C
solubility H2O: >10 mg/mL
form A crystalline solid
EPA Substance Registry SystemMorphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, hydrochloride (1:1), (5.alpha.) (71-68-1)
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 16-36/37-45
RIDADR UN 1230 3/PG 2
WGK Germany 3
RTECS QD2625000
HazardClass 6.1(a)
PackingGroup II
HS Code 2939110000
ToxicityLD50 in mice (mg/kg): 61-96 i.v. (Buchwald, Eadie)
MSDS Information
ProviderLanguage
SigmaAldrich English
Hydromorphone hydrochloride Usage And Synthesis
DescriptionHydromorphone hydrochloride is a pure opioid agonist with the principal therapeutic activity of analgesia. It has an analgesic potency approximately two to eight times greater than that of morphine and has a rapid onset of action. A significant feature of the analgesia is that it can occur without loss of consciousness.
Chemical PropertiesWhite Solid
UsesAnalgesic (narcotic). Preparation by electrolytic reduction of Morphine. Controlled substance (opiate).
Biochem/physiol ActionsNarcotic opiate analgesic; μ opioid receptor agonist.
Clinical UseHydromorphone is a potent μ agonist (eight times greater than morphine) that is used to treat severe pain. It is available in intramuscular, intravenous, subcutaneous, oral, and rectal dosage forms. Like all strong μ agonists, hydromorphone is addicting and is a Schedule II drug. Hydromorphone has an oral:parenteral potency ratio of 5:1. The plasma half-lives after parenteral and oral dosage are 2.5 and 4 hours, respectively.
Safety ProfilePoison by subcutaneous and intravenous routes. Experimental teratogenic effects. A powerful analgesic. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also MORPHINE.
Drug interactionsPotentially hazardous interactions with other drugs
Alcohol: can cause dose dumping with sustained release preparations.
Analgesics: possible opioid withdrawal effects with buprenorphine and pentazocine.
Antidepressants: possible CNS excitation or depression with MAOIs - avoid concomitant use and for 2 weeks after stopping MAOI; possible CNS excitation or depression with moclobemide; increased sedative effects with tricyclics.
Antihistamines: increased sedative effects with sedating antihistamines.
Antipsychotics: enhanced hypotensive and sedative effects.
Dopaminergics: avoid with selegiline.
Nalmefene: avoid concomitant use.
Sodium oxybate: enhanced effect of sodium oxybate - avoid.
MetabolismHydromorphone undergoes extensive firstpass metabolism. It is extensively metabolised by glucuronidation in the liver and excreted in the urine mainly as conjugated hydromorphone, dihydroisomorphine, and dihydromorphine.
Hydromorphone hydrochloride Preparation Products And Raw materials
Preparation ProductsHYDROMORPHONE-->β-Hydromorphol
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