| Company Name: |
Sigma-Aldrich
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| Products Intro: |
Product Name:Cibenzoline succinate
CAS:100678-32-8
Purity:>=97% (NMR), solid Package:50MG Remarks:C1618-50MG
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| | Cibenzoline succinate Basic information |
| Product Name: | Cibenzoline succinate | | Synonyms: | (+-)-2-(2,2-diphenylcyclopropyl)-2-imidazolinesuccinate(1:1);ole(1:1);ritmalan;ro22-7796/001;succinic acid, compound with 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole (1:2);2-(2,2-Diphenylcyclopropyl)-4,5-dihydro-1H-imidazole succinate;2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole succinate, Cibenol, Cipralan, Exacor;Cinobezile | | CAS: | 100678-32-8 | | MF: | C18H18N2.C4H6O4 | | MW: | 380.44 | | EINECS: | 634-471-4 | | Product Categories: | Heterocyclic Compounds | | Mol File: | 100678-32-8.mol |  |
| | Cibenzoline succinate Chemical Properties |
| Melting point | 165° | | storage temp. | 2-8°C | | solubility | H2O: ≥5mg/mL | | form | solid | | color | white to off-white | | Stability: | Light Sensitive |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 | | RTECS | EJ9960100 |
| | Cibenzoline succinate Usage And Synthesis |
| Uses | Cardiac
depressant (anti-arrhythmic). | | Uses | Cibenzoline Succinate acts as a highly active class I antiarrhythmic agent. | | Definition | ChEBI: Cibenzoline succinate is a diarylmethane. | | General Description | Cibenzoline also called (±)-2-(2,2-diphenylcyclopropyl)-2-imidazoline succinate, is generally used in stereo combination of R(+) and S(?) forms. It also exhibits anticholinergic activity.. Cibenzoline is known to improve left ventricular diastolic dysfunction by reducing left ventricular pressure gradient. | | Biochem/physiol Actions | Cibenzoline is a class IA antiarrhythmic drug. Cibenzoline (μM concentrations) blocks ATP-sensitive K channels in heart and pancreatic cells. Cibenzoline interacts with the channel pore-forming subunit of the K(ATP) channel (Kir6.2) from the cytoplasmic side. Cibenzoline also inhibits the delayed rectifier K current [I(Kr)] in sino-atrial node cells. |
| | Cibenzoline succinate Preparation Products And Raw materials |
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