Resolvin D2
| 中文名称 | Resolvin D2 |
|---|---|
| 中文同义词 | |
| 英文名称 | Resolvin D2 |
| 英文同义词 | IKFAUGXNBOBQDM-XFMPMKITSA-N;RvD2;4,8,10,12,14,19-Docosahexaenoic acid, 7,16,17-trihydroxy-, (4Z,7S,8E,10Z,12E,14E,16R,17S,19Z)- |
| CAS号 | 810668-37-2 |
| 分子式 | C22H32O5 |
| 分子量 | 376.49 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 810668-37-2.mol |
| 结构式 |  |
Resolvin D2 性质
| 沸点 | 609.2±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.101±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -80°C,protect from light |
| 溶解度 | DMF：50mg/mL；乙醇：50mg/mL； PBS（pH 7.2）：0.05 mg/mL |
| 酸度系数(pKa) | 4.58±0.10(Predicted) |
| 形态 | 液体 |
| 颜色 | 无色至浅黄 |
Resolvin D2 是 DHA 的代谢物，具有抗炎和抗感染活性。Resolvin D2 是一种高效的白细胞调节器，能控制微生物败血症。在原代感觉神经元中，Resolvin D2 是 TRPV1 (IC50 = 0.1 nM) 和 TRPA1 (IC50 = 2 nM) 的有效抑制剂。
TRP Channel
Resolvin D2 induces active resolution of inflammation with pulp-like tissue regeneration after root canal infection and thus maybe suitable for treating periapical lesions.
Resolvin D2 decreases leukocyte:endothelial interactions in vivo by endothelial-dependent nitric oxide production, and direct modulation of leukocyte adhesion receptor expression.
Peripheral administration of Resolvin D2 (10 ng; Intraplantar administration) potently inhibits inflammatory pain.
| Animal Model: | Adult CD1 mice (male, 8–10 weeks) |
| Dosage: | 10 ng |
| Administration: | Intraplantar administration |
| Result: | Inhibited inflammatory pain. |