| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:Resolvin D2
CAS:810668-37-2
Purity:>98% Package:1mg;10mg;50mg;100mg;
|
| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Resolvin D2
CAS:810668-37-2
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:Resolvin D2
CAS:810668-37-2
Package:25μg/RMB 6330
|
Resolvin D2 manufacturers
- Resolvin D2
-
- $886.00 / 25μg
-
2024-11-04
- CAS:810668-37-2
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | Resolvin D2 Basic information |
| Product Name: | Resolvin D2 | | Synonyms: | IKFAUGXNBOBQDM-XFMPMKITSA-N;RvD2;4,8,10,12,14,19-Docosahexaenoic acid, 7,16,17-trihydroxy-, (4Z,7S,8E,10Z,12E,14E,16R,17S,19Z)- | | CAS: | 810668-37-2 | | MF: | C22H32O5 | | MW: | 376.49 | | EINECS: | | | Product Categories: | | | Mol File: | 810668-37-2.mol |  |
| | Resolvin D2 Chemical Properties |
| Boiling point | 609.2±55.0 °C(Predicted) | | density | 1.101±0.06 g/cm3(Predicted) | | storage temp. | Store at -80°C,protect from light | | solubility | DMF: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): .05 mg/ml | | pka | 4.58±0.10(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | Resolvin D2 Usage And Synthesis |
| Description | Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA; ) and docosahexaenoic acid (DHA; ). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. Resolvin D2 (RvD2) is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase and functions to dampen excessive neutrophil trafficking to sites of inflammation. It reduces zymosan-stimulated PMN infiltration by 70% at doses as low as 10 pg per mouse and significantly reduces PAF-stimulated leukocyte adherence and emigration at 1 nM. Also, by stimulating nitric oxide production, RvD2 dose dependently decreases leukocyte-endothelial interactions. In a mouse model of sepsis, RvD2 reduces leukocyte and PMN infiltration, decreases production of pro-inflammatory cytokines, and promotes phagocyte-mediated bacterial clearance. Analytical and biological comparisons of synthetic RvD2 with endogenously derived RvD2 have confirmed its identity as matching the natural product. | | Uses | Resolvin D2 is a lipid mediator. | | Definition | ChEBI: Resolvin D2 is a member of the class of resolvins that is (4Z,8E,10Z,12E,14E,19Z)-docosahexaenoic acid carrying three hydroxy substituents at positions 7, 16 and 17 (the 7S,16R,17S-stereoisomer). It has a role as a human xenobiotic metabolite, an anti-inflammatory agent, an estrogen receptor agonist, an anti-obesity agent and a rat metabolite. It is a resolvin, a triol, a secondary allylic alcohol and a hydroxy polyunsaturated fatty acid. It is a conjugate acid of a resolvin D2(1-). |
| | Resolvin D2 Preparation Products And Raw materials |
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