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Product Name:VUF 5574;N-(2-Methoxyphenyl)-N'-[2-(3-pyrindinyl)-4-quinazolinyl]-urea
CAS:280570-45-8
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| | VUF 5574 Basic information |
| Product Name: | VUF 5574 | | Synonyms: | VUF 5574;N-(2-METHOXYPHENYL)-N-[2-(3-PYRIDINYL)-4-QUINAZOLINYL]-UREA;N-(2-METHOXYPHENYL)-N'-[2-(3-PYRINDINYL)-4-QUINAZOLINYL]-UREA;1-(2-Methoxy-phenyl)-3-(2-pyridin-3-yl-quinazolin-4-yl)-urea;Urea, N-(2-methoxyphenyl)-N'-[2-(3-pyridinyl)-4-quinazolinyl]-;3-(2-methoxyphenyl)-1-(2-pyridin-3-ylquinazolin-4-yl)urea | | CAS: | 280570-45-8 | | MF: | C21H17N5O2 | | MW: | 371.39 | | EINECS: | | | Product Categories: | Adenosine receptor | | Mol File: | 280570-45-8.mol |  |
| | VUF 5574 Chemical Properties |
| Melting point | 257-258 °C | | Boiling point | 444.8±45.0 °C(Predicted) | | density | 1.360±0.06 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | DMSO: 1.5 mg/mL, soluble | | form | solid | | pka | -2.06±0.43(Predicted) | | color | white |
| | VUF 5574 Usage And Synthesis |
| Description | VUF 5574 is an antagonist of the adenosine A3 receptor (Ki = 4.03 nM for the recombinant human receptor). It is greater than 2,500-fold selective for adenosine A3 over A1 and A2A receptors. VUF 5574 (100 nM) decreases phosphorylation of ERK1/2 induced by adenosine in isolated porcine coronary artery smooth muscle cells. It increases oxygen-glucose deprivation-induced reductions in the amplitude of field excitatory postsynaptic potentials (EPSPs) in a rat hippocampal slice model of ischemia when used at a concentration of 100 nM. VUF 5574 (2 μg, intracisternal) reduces sodium nitroprusside-induced heart rate increases in rats. | | Uses | VUF 5574 is an adenosine A3 receptor antagonist. | | Biological Activity | Potent, selective, competitive antagonist for the human adenosine A 3 receptor (K i = 4 nM). Displays ≥ 2500-fold selectivity over A 1 and A 2A receptors. |
| | VUF 5574 Preparation Products And Raw materials |
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