- 1-TRIMETHYLSILYLMETHANOL
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- $0.00 / 25kg
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2024-08-14
- CAS:3219-63-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 50000KG/month
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| 1-TRIMETHYLSILYLMETHANOL Basic information |
| 1-TRIMETHYLSILYLMETHANOL Chemical Properties |
Melting point | <0°C | Boiling point | 120-122 °C754 mm Hg(lit.) | density | 0.826 g/mL at 25 °C(lit.) | refractive index | n20/D 1.419(lit.) | Fp | 88 °F | storage temp. | 2-8°C | pka | 15.92±0.10(Predicted) | form | clear liquid | color | Colorless to Almost colorless | Specific Gravity | 0.827 | Water Solubility | Fully miscible in water. | Hydrolytic Sensitivity | 1: no significant reaction with aqueous systems | BRN | 1731486 | CAS DataBase Reference | 3219-63-4(CAS DataBase Reference) | EPA Substance Registry System | Methanol, (trimethylsilyl)- (3219-63-4) |
Hazard Codes | Xi | Risk Statements | 36/37/38 | Safety Statements | 26-36 | RIDADR | UN 1987 3/PG 3 | WGK Germany | 3 | RTECS | PC4100000 | TSCA | Yes | HS Code | 2931.90.9010 | HazardClass | 3 | PackingGroup | III |
| 1-TRIMETHYLSILYLMETHANOL Usage And Synthesis |
Uses | 1-Trimethylsilylmethanol is used as nucleophile to resolve the racemate obtained from enantioselective esterification of naproxen (2-(6-methoxy-2-naphthyl) propionic acid) by lipases. It was also used as a nucleophilic hydroxymethylation agent. | Purification Methods | If the NMR indicates impurities (should have only two signals), then dissolve it in Et2O, shake this with aqueous 5N NaOH, M H2SO4, saturated aqueous NaCl, dry (MgSO4) and distil it using an efficient column at atmospheric pressure. The 3,5-dinitrobenzoate has m 70-70.5o (from 95% EtOH). [Huang & Wang Acta Chem Sin 23 291 1957, cf. Chem Abstr 52 19911 1958, Speier et al. J Am Chem Soc 81 1844 1959 and Speier et al. J Am Chem Soc 70 1117 1948, Beilstein 4 III 1844, 4 IV 2876.] |
| 1-TRIMETHYLSILYLMETHANOL Preparation Products And Raw materials |
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