| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Purity:IgG fraction of antiserum, lyophilized powder Remarks:clone 2D2, purified immunoglobulin, buffered aqueous solution
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| | Anti-POU domain, class 2, transcription factor 2 Basic information |
| Product Name: | Anti-POU domain, class 2, transcription factor 2 | | Synonyms: | Anti-2-Oct;Anti-39723;Anti-OTF2;Anti-POU domain, class 2, transcription factor 2;Monoclonal Anti-POU2F2 antibody produced in mouse;Anti-MGC32628;Anti-solute carrier family 22 (organic cation transporter), member 2;Monoclonal Anti-SLC22A2 antibody produced in mouse | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Anti-POU domain, class 2, transcription factor 2 Structure]() |
| | Anti-POU domain, class 2, transcription factor 2 Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous glycerol solution |
| | Anti-POU domain, class 2, transcription factor 2 Usage And Synthesis |
| Uses | Monoclonal Anti-SLC22A2 antibody produced in mouse has been used in immunostaining. | | General Description | Solute carrier family 22 member 2 (SLC22A2) also known as organic cation transporter 2 (OCT2), is expressed prominently in the basolateral membrane of epithelial cells of kidney, especially in the proximal renal tubule. SLC22A2 possess 12 transmembrane domains and is the integral plasma membrane protein. In the human, SLC22A2 gene is mapped to chromosome 6q26. | | Biochem/physiol Actions | Solute carrier family 22 member 2 (SLC22A2) is involved in the transport of cationic substances like drugs, toxins, waste metabolites like creatinine, neurotransmitters etc., from the kidney. Expression of SLC22A2 in kidney is regulated by methylation of the promoter region. The major substrate for SLC22A2 is metformin, an anti-diabetic agent. Lack of SLC22A2 leads possibly to drug toxicity as these substances are not eliminated from the body. Imipramine, clonidine, verapamil, quinidine, carvedilol, interact with SLC22A2 by hydrophobic interaction and leads to its inhibition. |
| | Anti-POU domain, class 2, transcription factor 2 Preparation Products And Raw materials |
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