166882-70-8
中文名称 | 166882-70-8 |
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中文同义词 | 化合物 T10438;化合物 AZD 4407 |
英文名称 | 2H-Indol-2-one,1,3-dihydro-1-methyl-5-[[4-[(2S,4R)-tetrahydro-4-hydroxy-2-methyl-2H-pyran-4-yl]-2-thienyl]thio]- |
英文同义词 | 2H-Indol-2-one,1,3-dihydro-1-methyl-5-[[4-[(2S,4R)-tetrahydro-4-hydroxy-2-methyl-2H-pyran-4-yl]-2-thienyl]thio]-;AZD 4407;ZD 4407 |
CAS号 | 166882-70-8 |
分子式 | C19H21NO3S2 |
分子量 | 375.5 |
EINECS号 | |
相关类别 | |
Mol文件 | 166882-70-8.mol |
结构式 |
166882-70-8 性质
沸点 | 665.6±55.0 °C(Predicted) |
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密度 | 1.38±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | 13.68±0.40(Predicted) |
AZD 4407 是一种有效的 5-脂氧合酶 (5-lipoxygenase) 抑制剂。
5-Lipoxygenase
|
In view of the powerful spasmogenic actions of leukotrienes in vascular and bronchial tissue, drugs which block their biosynthesis by inhibiting 5-lipoxygenase may have therapeutic potential in a variety of inflammatory conditions including inflammatory arthropothies, asthma, psoriasis, and inflammatory bowel disease. One such compound is AZD 4407 (ZD4407).