YU238259
| 中文名称 | YU238259 |
|---|---|
| 中文同义词 | N-(2-(5-氯吡啶-2-基)乙基)-4-((4-甲氧基苯磺酰胺基)甲基)苯甲酰胺;化合物YU238259 |
| 英文名称 | YU238259 |
| 英文同义词 | YU238259;YU-238259;YU 238259;Benzamide, N-[2-(5-chloro-2-pyridinyl)ethyl]-4-[[[(4-methoxyphenyl)sulfonyl]amino]methyl]-;N-(2-(5-Chloropyridin-2-yl)ethyl)-4-(((4-methoxyphenyl)sulfonamido)methyl)benzamide;inhibit,Inhibitor,DNA-dependent protein kinase,DNA-PK,YU 238259,YU-238259,YU238259 |
| CAS号 | 1943733-16-1 |
| 分子式 | C22H22ClN3O4S |
| 分子量 | 459.95 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1943733-16-1.mol |
| 结构式 |  |
YU238259 性质
| 密度 | 1.323±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | DMF：30mg/mL； DMSO：30mg/mL； DMSO:PBS (pH 7.2) (1:10)：0.1 mg/mL |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 11.46±0.50(Predicted) |
| 颜色 | 白色至米白色 |
YU238259 是一种同源依赖性 DNA 修复 (HDR) 抑制剂，可用于癌症研究。
HDR
YU238259 is an inhibitor of homology-dependent DNA repair, with no effect on PARP activity. YU238259 shows cytotoxicity in BRCA2-deficient cells, with a low LD 50 of 8.5 μM. YU238259 (0-5 μM) causes a potent, dose-dependent decrease in HDR efficiency in U2OS DR-GFP or U2OS EJ5-GFP cells, but with no effect on NHEJ frequency. YU238259 (0-10 μM) exhibits synthetic lethality with loss of frequently mutated tumor suppressors, and shows synergism with radiotherapy (IR) and DNA-damaging chemotherapy that is potentiated by BRCA2 loss.
YU238259 (3 mg/kg, i.p.) inhibits the growth of BRCA2-deficient tumor xenografts in nude mice.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-19977 | YU238259 | 1 mg | 419元 | |
| 2024/04/30 | HY-19977 | YU238259 YU238259 | 1943733-16-1 | 5mg | 1100元 |