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Product Name:SB 218795;(R)-[[2-Phenyl-4-quinolinyl)carbonyl]aMino]-Methylesterbenzeneaceticacid
CAS:174635-53-1
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| | SB 218795 Basic information |
| Product Name: | SB 218795 | | Synonyms: | SB 218795;(-)-(R)-N-(ALPHA-METHOXYCARBONYLBENZYL)-2-PHENYLQUINOLINE-4-CARBOXAMIDE;(R)-[[(2-PHENYL-4-QUINOLINYL)CARBONYL]AMINO]-METHYL ESTER BENZENEACETIC ACID;(-)-(R)-N-(α-Methoxycarbonylbenzyl)-2-phenylquinoline-4-carboxamide;Benzeneacetic acid, alpha-(((2-phenyl-4-quinolinyl)carbonyl)amino)-, methyl ester, (alphar)-;Sb 218795r;methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate;constriction,SB-218795,Neurokinin Receptor,Inhibitor,neurokinin-3,NK receptor,pupillary,inhibit,Tachykinin receptor,SB218795,SB 218795,NK-3 | | CAS: | 174635-53-1 | | MF: | C25H20N2O3 | | MW: | 396.44 | | EINECS: | | | Product Categories: | | | Mol File: | 174635-53-1.mol |  |
| | SB 218795 Chemical Properties |
| Boiling point | 623.7±55.0 °C(Predicted) | | density | 1.237±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 40 mg/mL, soluble | | form | solid | | pka | 11.41±0.46(Predicted) | | color | white |
| | SB 218795 Usage And Synthesis |
| Uses | SB 218795 is an NK3 receptor antagonist. | | Definition | ChEBI: (2R)-2-[[oxo-(2-phenyl-4-quinolinyl)methyl]amino]-2-phenylacetic acid methyl ester is a member of quinolines. | | Biological Activity | Potent, selective and competitive non-peptide NK 3 receptor antagonist (K i = 13 nM at hNK 3 ). Displays 90-fold and 7000-fold selectivity over hNK 2 and hNK 1 receptors respectively. Active in vivo , inhibiting agonist-induced pupillary constriction. |
| | SB 218795 Preparation Products And Raw materials |
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