| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:AG 556;(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-2-propenaMide
CAS:133550-41-1
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
VDM Biochemicals
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| Tel: |
0330-2528181 |
| Email: |
sales@vdmbio.com |
| Products Intro: |
Product Name:AG 556
CAS:133550-41-1
Purity:>=95% Package:70USD/10mg
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| | TYRPHOSTIN B56 Basic information |
| Product Name: | TYRPHOSTIN B56 | | Synonyms: | ALPHA-CYANO-(3,4-DIHYDROXY)-N-(4-PHENYLBUTYL)CINNAMIDE;AG 556;(E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-(4-PHENYLBUTYL)-2-PROPENAMIDE;N-(4-PHENYLBUTYL)-3,4-DIHYDROXYBENZYLIDENE-CYANOACETAMIDE;TYRPHOSTIN B56;TYRPHOSTIN AG 556;(2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-2-propenamide;N-(4-Phenylbutyl)-3,4-dihydroxybenzylidenecyanoacetamide, Tyrphostin B56 | | CAS: | 133550-41-1 | | MF: | C20H20N2O3 | | MW: | 336.38 | | EINECS: | | | Product Categories: | Protein Kinase;Intracellular Signaling | | Mol File: | 133550-41-1.mol |  |
| | TYRPHOSTIN B56 Chemical Properties |
| storage temp. | −20°C | | solubility | DMSO: soluble | | form | Yellow solid. | | color | Light yellow to yellow |
| | TYRPHOSTIN B56 Usage And Synthesis |
| Uses | AG 556 is a highly selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TK inhibitor). AG 556 has been shown to decrease human atrial IKur and cloned hKv1.5 channels by inhibiting EGFR TK. | | Biological Activity | Epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 1.1 μ M). Selective over ErbB2 (IC 50 > 500 μ M). | | references | [1]. zhang dy, zhang yh, sun hy, et al. epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium k(ir)2.3 channel, stably expressed in hek 293 cells. br j pharmacol, 2011 nov, 164(5): 1469-1478
[1].
[2]. zhang dy, wu w, deng xl, et al. genistein and tyrphostin ag556 inhibit inwardly-rectifying kir2.1 channels expressed in hek 293 cells via protein tyrosine kinase inhibition. biochim biophys acta, 2011, 1808(8): 1993-1999.
[3]. kleinberger-doron n, shelah n, capone r, et al. inhibition of cdk2 activation by selected tyrphostins causes cell cycle arrest at late g1 and s phase. exp cell res, 1998, 241(2): 340-351.
[4]. sevransky je, shaked g, novogrodsky a, et al. tyrphostin ag 556 improves survival and reduces multiorgan failure in canine escherichia coli peritonitis. j clin invest, 1997, 99(8): 1966-1973. |
| | TYRPHOSTIN B56 Preparation Products And Raw materials |
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