(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
| 中文名称 | (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE |
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| 中文同义词 | (ALPHAS)-ALPHA-氨基-4-羧基-ALPHA-甲基-苯乙酸;(+)-MCPG, 99.0+ % (HPLC);(+)-Α-METHYL-4-CARBOXYPHENYLGLYCINE;(S)-ALPHA-甲基-4-羧基苯甘氨酸;(+)-Α-甲基-4-羧基苯基甘氨酸;化合物 T13452;化合物 (S)-MCPG |
| 英文名称 | (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE |
| 英文同义词 | (S)-MCPG;S(+)-ALPHA-AMINO-4-CARBOXY-ALPHA-METHYL-BENZENEACETIC ACID;(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE;4-((1S)-1-AMINO-1-CARBOXYETHYL)BENZOIC ACID;(+)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE;(S)-ALFA-METHYL-4-CARBOXYPHENYLGLYCINE;(S)-alpha-Methyl-4-carboxyphenylglycine(S)-MCPG;(+)-MCPG |
| CAS号 | 150145-89-4 |
| 分子式 | C10H11NO4 |
| 分子量 | 209.2 |
| EINECS号 | |
| 相关类别 | Glutamate receptor;Glutamate |
| Mol文件 | 150145-89-4.mol |
| 结构式 |  |
(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE 性质
| 沸点 | 425.3±40.0 °C(Predicted) |
|---|---|
| 密度 | 1.390±0.06 g/cm3(Predicted) |
| 储存条件 | Store at RT |
| 溶解度 | 0.1MNaOH：15 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 1.76±0.10(Predicted) |
| 颜色 | 白色至类白色 |
| 旋光性 (optical activity) | [α]20/D +89.54°, c = 0.33 in 6 M HCl(lit.) |
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mGluR
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(S)-MCPG (100 μM) has no detectable effects on basal spine formation or elimination mechanisms in WT slice cultures. (S)-MCPG prevents the increase in spine turnover triggered by TBS and interferes with the mechanisms of activity-dependent spine stabilization in Hippocampal slice cultures.
MCPG (intraventricular injection; 20 μg) treated rat are slower to learn the task and takes longer to reach the platform than vehicle injected animals. On days 2 and 3, MCPG rats has a significant longer escape latency and the measure of search error is significantly longer on each of the first 3 days. On day 4, MCPG-treated animals reaches the same level of performance as control animals in Morris water maze.
| Animal Model: | Male Lister-Hooded rats in the learning of the Morris water maze |
| Dosage: | 20 μg |
| Administration: | Intraventricular injection; 20 μg; 4 days |
| Result: | Impaired the performance of rats in the spatial version of the Morris water maze, but 1/10 of this dose did not. |
安全信息
| 安全说明 | 24/25 |
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| WGK Germany | 3 |
| 海关编码 | 29224985 |
| 提供商 | 语言 |
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-100406 | (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE (S)-MCPG | 150145-89-4 | 5mg | 800元 |
| 2024/11/08 | HY-100406 | (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE (S)-MCPG | 150145-89-4 | 10mg | 1100元 |