Belzutifan manufacturers
- Belzutifan
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- $780.00 / 1g
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2024-05-28
- CAS:1672668-24-4
- Min. Order: 1g
- Purity: 98
- Supply Ability: 500 Kg
Related articles - How is Belzutifan synthesised?
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- Jan 29,2024
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| Belzutifan Basic information |
Product Name: | Belzutifan | Synonyms: | Benzonitrile, 3-[[(1S,2S,3R)-2,3-difluoro-2,3-dihydro-1-hydroxy-7-(methylsulfonyl)-1H-inden-4-yl]oxy]-5-fluoro-;PT2977 (MK-6482);Belzutifan (MK-6482);Belzutifan (PT2977, MK-6482);HY-125840 Belzutifan PT2977;PT2977;MK-6482;Belzutifan | CAS: | 1672668-24-4 | MF: | C17H12F3NO4S | MW: | 383.34 | EINECS: | | Product Categories: | | Mol File: | 1672668-24-4.mol | ![Belzutifan Structure](CAS/20200401/GIF/1672668-24-4.gif) |
| Belzutifan Chemical Properties |
Boiling point | 505.8±50.0 °C(Predicted) | density | 1.56±0.1 g/cm3(Predicted) | storage temp. | Store at -20°C, stored under nitrogen | solubility | DMSO: 50 mg/mL (130.43 mM) | form | Solid | pka | 11.66±0.60(Predicted) | color | White to light yellow |
| Belzutifan Usage And Synthesis |
Description | Belzutifan is an orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha (HIF-2a), with potential antineoplastic activity. The HIF-2α protein was a key player in the growth of certain cancers. Initially considered to be undruggable, a binding pocket was eventually discovered in the HIF-2α molecule which allowed for compounds to bind and inhibit these proteins. | Uses | Belzutifan is a prescription medicine used to treat adults with von Hippel-Lindau (VHL) disease who need treatment for a type of kidney cancer called renal cell carcinoma (RCC), tumors in the brain and spinal cord called central nervous system hemangioblastomas, or a type of pancreatic cancer called pancreatic neuroendocrine tumors, that do not need surgery right away. | Indications | Belzutifan is indicated for the treatment of adult patients with von Hippel-Lindau (VHL) disease who require therapy for associated renal cell carcinoma (RCC), central nervous system (CNS) hemangioblastomas, or pancreatic neuroendocrine tumors (pNET), who do not require immediate surgery. | Mechanism of action | Belzutifan inhibits the complexation of HIF-2α with another transcription factor, HIF-1β, a necessary step in its activation - by preventing the formation of this complex, belzutifan can slow or stop the growth of VHL-associated tumors. Belzutifan received FDA approval for the treatment of select VHL-associated cancers on August 13, 2021. | Pharmacokinetics | Upon oral administration, belzutifan binds to and blocks the function of HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate hypoxic signaling. This inhibits cell growth and survival of HIF-2alpha-expressing tumor cells. HIF-2alpha, the alpha subunit for the heterodimeric transcription factor HIF-2, is overexpressed in many cancers and promotes tumorigenesis. | Side effects | Side effects ofBelzutifan that was reported: allergic reactions(skin rash,itchingorhives; swelling of the face, lips, or tongue) blurred vision OR changes in vision high blood sugar (increased hunger, thirst or urination; unusually weak or tired, blurry vision) infection (fever, chills,cough,sore throat,pain;or trouble passing urine) low calcium levels(fast heartbeat; muscle cramps or;pain;;pain, tingling, or numbness in the hands or feet; seizures) low red blood cell counts (feeling faint; lightheaded, falls; unusually weak or tired) trouble breathing trouble passing urine or change in the amount of urine |
| Belzutifan Preparation Products And Raw materials |
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