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ACBI1

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ACBI1 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:ACBI1
CAS:2375564-55-7
Purity:98.15% Package:1mg;59USD|5mg;142USD|10mg;229USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:ACBI1
CAS:2375564-55-7
Purity:99% Package:1g;1USD
Company Name: Nantong HI-FUTURE Biology Co., Ltd.
Tel: +undefined18051384581
Email: sales@chemhifuture.com
Products Intro: Product Name:ACBI1
CAS:2375564-55-7
Purity:98%+ HPLC Package:100MG,500MG,1G,5G,10G 50MG
Company Name: Hebei Miaoyin Technology Co.,Ltd
Tel: +86-17367732028 +86-17367732028
Email: kathy@hbyinsheng.com
Products Intro: Product Name:ACBI1
CAS:2375564-55-7
Purity:99.9% Package:1g;1USD
Company Name: LEAPCHEM CO., LTD.
Tel: +86-852-30606658
Email: market18@leapchem.com
Products Intro: Product Name:ACBI1
CAS:2375564-55-7
Purity:0 Package:1g; 5g; 25g; 1kg; 5kg; 25kg Remarks:0

ACBI1 manufacturers

  • ACBI1
  • ACBI1 pictures
  • $200.00 / 100MG
  • 2024-11-19
  • CAS:2375564-55-7
  • Min. Order: 1MG
  • Purity: 98
  • Supply Ability: 100G
  • ACBI-1
  • ACBI-1 pictures
  • $0.00 / 100MG
  • 2024-11-19
  • CAS:2375564-55-7
  • Min. Order: 1MG
  • Purity: 98
  • Supply Ability: 100G
  • ACBI1
  • ACBI1 pictures
  • $98.00 / 1mg
  • 2024-11-18
  • CAS:2375564-55-7
  • Min. Order:
  • Purity: 98.15%
  • Supply Ability: 10g
ACBI1 Basic information
Product Name:ACBI1
Synonyms:ACBI1;PROTACs,anti-proliferative,ACBI 1,Epigenetic Reader Domain,ACBI1,Inhibitor,Apoptosis,inhibit,ACBI-1;N-[(1-Fluorocyclopropyl)carbonyl]-3-methyl-L-valyl-(4R)-N-[2-{2-[4-({4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-1-piperazinyl}methyl)phenoxy]ethoxy}-4-(4-methyl-1,3-thiazol-5-yl)benzyl]-4-hydroxy-L-prolinamide;(2S,4R)-N-(2-(2-(4-((4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)methyl)phenoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide
CAS:2375564-55-7
MF:C49H58FN9O7S
MW:936.12
EINECS:
Product Categories:
Mol File:2375564-55-7.mol
ACBI1 Structure
ACBI1 Chemical Properties
Boiling point 1144.1±65.0 °C(Predicted)
density 1.41±0.1 g/cm3(Predicted)
pka6.22±0.30(Predicted)
form Solid
color White to yellow
InChIKeyIVARZBJJMMUJHI-SSIILETPNA-N
SMILESNC1N=NC(C2C=CC=CC=2O)=CC=1N1CCN(CC2C=CC(OCCOC3C=C(C4SC=NC=4C)C=CC=3CNC([C@@H]3C[C@@H](O)CN3C(=O)[C@H](C(C)(C)C)NC(C3(CC3)F)=O)=O)=CC=2)CC1 |&1:42,44,50,r|
Safety Information
MSDS Information
ACBI1 Usage And Synthesis
DefinitionACBI1 is a potent and cooperative SMARCA2, SMARCA4 and PBRM1 degrader with DC50s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity and can induce apoptosis. It induced anti-proliferative effects and cell death caused by SMARCA2 depletion in SMARCA4 mutant cancer cells and acute myeloid leukemia cells dependent on SMARCA4 ATPase activity[1].
References[1] William Farnaby. “BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.” Nature chemical biology 15 7 (2019): 672–680.
[2] M. Koegl. “Abstract 3849: Structure-based PROTAC design demonstrates BAF complex ATPase vulnerabilities in cancer.” Experimental and Molecular Therapeutics 36 1 (2019).
ACBI1 Preparation Products And Raw materials
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