Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
|
Tel: |
821-50328103-801 18930552037 |
Email: |
3bsc@sina.com |
Products Intro: |
Product Name:ChroManol 293B;trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-diMethyl-2H-1-benzopyran-4-yl]-N-Methyl-ethanesulfonaMide CAS:163163-23-3 Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
|
Company Name: |
BOC Sciences
|
Tel: |
1-631-485-4226; 16314854226 |
Email: |
info@bocsci.com |
Products Intro: |
Product Name:Chromanol 293B CAS:163163-23-3 Purity:99% by HPLC Remarks:Chromanol 293B is a specific slow delayed rectifier K+ current (IKs) blocker with an IC50 value of 6.89 μM in xenopus oocytes expressing rat. It shows no activity at rat Kv1.1 or Kir2.1 channels at a
|
Company Name: |
Sigma-Aldrich
|
Tel: |
021-61415566 800-8193336 |
Email: |
orderCN@merckgroup.com |
Products Intro: |
Product Name:Chromanol 293B CAS:163163-23-3 Purity:>=98% (HPLC), powder Package:10MG Remarks:C2615-10MG
|
|
| CHROMANOL 293B Basic information |
Product Name: | CHROMANOL 293B | Synonyms: | TRANS-N-[6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-METHYL-ETHANESULFONAMIDE;CHROMANOL 293B;6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane;N-[(3R,4S)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide;Chromagnol;Ethanesulfonamide, N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-, rel-;Chromanol 293B >=98% (HPLC), powder | CAS: | 163163-23-3 | MF: | C15H20N2O4S | MW: | 324.4 | EINECS: | | Product Categories: | Potassium channel | Mol File: | 163163-23-3.mol | ![CHROMANOL 293B Structure](CAS/GIF/163163-23-3.gif) |
| CHROMANOL 293B Chemical Properties |
Boiling point | 474.1±55.0 °C(Predicted) | density | 1.33±0.1 g/cm3(Predicted) | storage temp. | -20°C | solubility | DMSO: 18 mg/mL | pka | 12.96±0.60(Predicted) | form | solid | color | white |
| CHROMANOL 293B Usage And Synthesis |
Description | Chromanol 293B is a blocker of slowly activating delayed-rectifier K+ current (IKs) with an IC50 value of 6.89 μM in Xenopus oocytes expressing rat IKs channels. It is selective, having no activity at rat Kv1.1 or Kir2.1 channels at a concentration of 30 μM. Chromanol 293B increases the rate and extent of IKs in guinea pig ventricular cells in a dose-dependent manner. It also inhibits cystic fibrosis transmembrane conductance regulator (CTFR) Cl- currents (ICTFR) with an IC50 value of 19 μM in Xenopus oocytes expressing human CTFR. | Uses | Chromanol 293B has been used in the inhibition of calcium and cyclic adenosine monophosphate (cAMP)-activated potassium channels in human epithelial cell lines. Chromanol 293B has been used in patch-clamp electrophysiology studies in cardiomyocytes. | Definition | ChEBI: Chromanol 293B is a 1-benzopyran. | General Description | Chromanol 293B enantiomer is a potent inhibitor of potassium channel protein (KvLQT1). In human atrial myocytes, chromanol 293B inhibits repolarization potassium currents. Chromanol 293B improves glucose-stimulated insulin secretion (GSIS) in pancreas by modulating potassium voltage-gated channel (KCNQ1). | Biological Activity | Blocker of the slow delayed rectifier K + current (I Ks ) (IC 50 = 1-10 μ M). Also blocks the CFTR chloride current (I CFTR ) (IC 50 = 19 μ M). | Biochem/physiol Actions | Blocker of the slow delayed rectifier K+ current via KCNQ1 channels | storage | Room temperature |
| CHROMANOL 293B Preparation Products And Raw materials |
|