焦脱镁叶绿酸Α甲酯
| 中文名称 | 焦脱镁叶绿酸Α甲酯 |
|---|---|
| 中文同义词 | 焦脱镁叶绿酸Α甲酯;焦脱镁叶绿酸-ALPHA 甲酯;焦脱镁叶绿酸A甲酯杂质;叶绿素杂质5;焦脱镁叶绿酸Α甲酯;总叶绿素杂质5;化合物 T33492 |
| 英文名称 | MPP A |
| 英文同义词 | 9-Ethenyl-14-ethyl-4,8,13,18-tetramethyl-20-oxophorbine-3-propanoi;Pyropheophorbide α Methyl Ester;MPP A;PYROPHEOPHORBIDE A METHYL ESTER;3-Phorbinepropanoic acid, 9-ethenyl-14-ethyl-4,8,13,18-tetramethyl-20-oxo-, methyl ester, (3S-trans)-;3-Phorbinepropionic acid, 14-ethyl-4,8,13,18-tetramethyl-20-oxo-9-vinyl-, methyl ester;9-Ethenyl-14-ethyl-4,8,13,18-tetramethyl-20-oxophorbine-3-propanoicacid meth;Methyl pyrophaeophorbide a |
| CAS号 | 6453-67-4 |
| 分子式 | C34H36N4O3 |
| 分子量 | 548.67 |
| EINECS号 | |
| 相关类别 | Natural Porphyrins and Derivitives;Porphyrins |
| Mol文件 | 6453-67-4.mol |
| 结构式 |  |
焦脱镁叶绿酸Α甲酯 性质
| 沸点 | 937.4±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.219±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | 氯仿（微溶）、甲醇（微溶、加热） |
| 形态 | 固体 |
| 颜色 | 黑色 |
| 稳定性 | 感光 |
Pyropheophorbide-a methyl ester (2 μM; 12 h) inhibits the cell cycle progression from the G0/G1-phases and induces apoptosis at the light dosage of 55.6 kJ/m
2
in PC-3M cells.
Pyropheophorbide-a methyl ester (0.2-15 μM; 20 h) has no significant dark cytotoxicity in NCI-h446 cells.
Pyropheophorbide-a methyl ester (0.1-15 μM; 20 h) mediates a dose-dependent photocytotoxicity in the NCI-h446 cells.
Pyropheophorbide-a methyl ester (2-4 μM; 0-24 h) induces apoptosis of NCI-h446 cells in a time-dependent manner.
Pyropheophorbide-a methyl ester (0.5-4 μM; 0-20 h) shows a photocytotoxicity in PC-3M cells.
Apoptosis Analysis
| Cell Line: | PC-3M cells |
| Concentration: | 2 μM |
| Incubation Time: | 12 h |
| Result: | Apoptosis rate was about 0.27%, 6.15%, 20.49%, 50.76%, 65.39%, 64.92%, and 64.37% at 1, 3, 6, 12, 18, and 24 h posttreatment, respectively under the conditions of LC 75 (2 μM+55.6 kJ/m 2 ). |
Pyropheophorbide-a methyl ester (15 mg/kg; tail vein and topical injection) inhibits the growth of PC-3M tumors in mice.
| Animal Model: | Male BALB/c nude mice (6-8 weeks, 16-20 g) bearing PC-3M tumor |
| Dosage: | 15 mg/kg |
| Administration: | Tail vein injection and topical injection |
| Result: | The tumor volume and the weight inhibition rate were 46.78%, 41.84% in tail vein injection group and 78.66%, 72.07% in topical injection group, respectively. |
安全信息
| WGK Germany | 3 |
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| 提供商 | 语言 |
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英文
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