H-丝氨酰亮氨酰异亮氨酰甘氨酰赖氨酰缬氨酰NH2

H-丝氨酰亮氨酰异亮氨酰甘氨酰赖氨酰缬氨酰NH2

中文名称H-丝氨酰亮氨酰异亮氨酰甘氨酰赖氨酰缬氨酰NH2
中文同义词H-丝氨酰亮氨酰异亮氨酰甘氨酰赖氨酰缬氨酰NH2;PROTEASE-ACTIVATED RECEPTOR-2, PAR-2 AGONIST, AMIDE肽;蛋白酶激活的受体-2,酰胺;PAR2-AP(SLIGKV-NH2);活化肽PROTEASE-ACTIVATED RECEPTOR-2, AMIDE;蛋白酶活化的受体-2,酰胺、PROTEASE-ACTIVATED RECEPTOR-2, AMIDE
英文名称H-SER-LEU-ILE-GLY-LYS-VAL-NH2
英文同义词PROTEASE-ACTIVATED RECEPTOR-2 AGONIST, AMIDE;PROTEINASE ACTIVATED RECEPTOR 2 (1-6) AMIDE (HUMAN);PROTEINASE ACTIVATED RECEPTOR 2 AGONIST PEPTIDE SLIGKV AMIDE, HUMAN;SER-LEU-ILE-GLY-LYS-VAL-AMIDE;SER-LEU-ILE-GLY-LYS-VAL-NH2;SLIGKVAMIDE;SLIGKV-NH2;PAR-2 AGONIST PEPTIDE (SLIGKV) AMIDE, HUMAN
CAS号190383-13-2
分子式C28H54N8O7
分子量614.78
EINECS号
相关类别多肽;标准品;目录多肽;peptide;Immune Cell Signaling and Blood;Immune System Regulation;Immunomodulators and Antibiotics
Mol文件190383-13-2.mol
结构式H-丝氨酰亮氨酰异亮氨酰甘氨酰赖氨酰缬氨酰NH2 结构式

H-丝氨酰亮氨酰异亮氨酰甘氨酰赖氨酰缬氨酰NH2 性质

沸点1030.3±65.0 °C(Predicted)
密度1.161±0.06 g/cm3(Predicted)
储存条件-20°C
溶解度≥13.48 mg/mL,乙醇溶液,温和加热和超声波; DMSO 中≥62.9 mg/mL;水中≥66.2 mg/mL
形态固体
酸度系数(pKa)12.04±0.10(Predicted)
颜色白色至米白色
水溶解性Soluble to 1 mg/ml in water
序列H-Ser-Leu-Ile-Gly-Lys-Val-NH2

H-丝氨酰亮氨酰异亮氨酰甘氨酰赖氨酰缬氨酰NH2 用途与合成方法

Protease-Activated Receptor-2, amide (SLIGKV-NH2) 是一种高效的蛋白酶活化受体-2 (PAR2) 活化肽。

PAR2

The PAR2-activating peptides used are: SLIGKV-OH, SLIGRL-OH, SLIGKV-NH 2 , SLIGRL-NH 2 . The synthetic agonist peptides mimicking the tethered ligand of PAR2, Ser-Leu-Ile-Gly-Lys-Val (SLIGKV-OH), Ser-Leu-Ile-Gly-Arg-Leu (SLIGRL-OH) and their amidated forms Ser-Leu-Ile-Gly-Lys-Val-amide (SLIGKV-NH 2 ) Ser-Leu-Ile-Gly-Arg-Leu-amide (SLIGRL-NH 2 ) have also been demonstrated being able to activate the receptor without enzymatic cleavage, therefore, have been utilised as biological tools to examine physiological functions of PAR2. Protease-Activated Receptor-2, amide is one of a four family subgroup of G-protein-coupled receptors (GPCRs), called PARs. Protease-activated receptors are distinguished from other GPCRs through their unique proteolytic mechanism of activation. For PAR2, activating proteases, such as trypsin, tryptase and coagulation factors VIIa and Xa, cleave a specific extracellular amino-terminal domain of the receptor to reveal a "tethered ligand", SLIGKV- and SLIGRL- for human and mouse/rat PAR2, respectively, which subsequently interacts with the activation domain of the receptor, initiating intracellular signaling pathways. The protease-activated receptor-2 (PAR2) has been implicated in the pathogenesis of several inflammatory and autoimmune disorders, and is expressed in a wide variety of human tissues and cells. PAR2 belongs to a family of seven transmembrane domain receptor proteins that are activated by proteolysis. Enzymatic digestion exposes an N-terminus ligand sequence that binds intramolecularly to the activation site on the extracellular loop II, initiating a G-protein-mediated cell-signalling cascade and nuclear factor-kappa B (NF-κB)-regulated gene transcription.

参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%

安全信息

安全说明22-24/25
WGK Germany3

MSDS信息

提供商 语言
英文

H-丝氨酰亮氨酰异亮氨酰甘氨酰赖氨酰缬氨酰NH2 上下游产品信息

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