ChemicalBook > Product Catalog >API >Hormones and the Endocrine System >Estrogen and progestin drugs >Allylestrenol

Allylestrenol

Allylestrenol Suppliers list
Company Name: Wuhan Haorong Biotechnology Co.,ltd
Tel: +86-18565342920; +8618565342920
Email: sales@chembj.net
Products Intro: Product Name:Allylestrenol
CAS:432-60-0
Purity:99% Package:1KG;|10KG;|25KG
Company Name: Nantong Guangyuan Chemicl Co,Ltd
Tel: +undefined17712220823
Email: admin@guyunchem.com
Products Intro: Product Name:Allylestrenol
CAS:432-60-0
Purity:99% Package:1kg;10.00;USD
Company Name: Hebei Kangcang new material Technology Co., LTD
Tel: +8615713292910
Email: Nancy@kangcang.com.cn
Products Intro: Product Name:Allylestrenol
CAS:432-60-0
Purity:99% Package:1g;9USD|10g;60USD
Company Name: BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Tel: +86-18600796368 +86-18600796368
Email: sales@sjar-tech.com
Products Intro: Product Name:Allylestrenol
CAS:432-60-0
Purity:More Than 99% Package:1g
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-(0)57185586718 +86-13336195806
Email: sales@capot.com
Products Intro: Product Name:Allylestrenol
CAS:432-60-0
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg

Allylestrenol manufacturers

  • Allylestrenol
  • Allylestrenol pictures
  • $0.00 / 1KG
  • 2024-11-27
  • CAS:432-60-0
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 5000
  • Allylestrenol
  • Allylestrenol pictures
  • $30.00 / 1mL
  • 2024-11-19
  • CAS:432-60-0
  • Min. Order:
  • Purity: 100%
  • Supply Ability: 10g
  • Allylestrenol
  • Allylestrenol pictures
  • $0.00 / 1g
  • 2024-11-18
  • CAS:432-60-0
  • Min. Order: 1g
  • Purity: More Than 99%
  • Supply Ability: 100kg/Month
Allylestrenol Basic information
Product Name:Allylestrenol
Synonyms:17-allylestr-4-en-17-beta-ol;17-alpha-allyl-17-beta-hydroxy-4-estrene;17-alpha-allyl-17-beta-hydroxy-delta(sup4)-estren;17-alpha-allyl-3-deoxy-19-nortestosterone;17-alpha-allyl-4-estren-17-beta-ol;17-alpha-allyl-4-oestrene-17-beta-ol;17-alpha-allylestr-4-en-17-beta-ol;17-alpha-allylhydroxy-19-nor-4-androstene
CAS:432-60-0
MF:C21H32O
MW:300.48
EINECS:207-082-9
Product Categories:Steroid and Hormone;Inhibitors;Medicine intermediate
Mol File:432-60-0.mol
Allylestrenol Structure
Allylestrenol Chemical Properties
Melting point 79.5-80°
Boiling point 381.7°C (rough estimate)
density 0.9914 (rough estimate)
refractive index 1.4800 (estimate)
storage temp. -20°C Freezer
solubility Chloroform (Slightly), Methanol (Slightly)
pka14.95±0.40(Predicted)
form Solid
color White to Pale Yellow
Merck 14,291
CAS DataBase Reference432-60-0(CAS DataBase Reference)
Safety Information
RTECS KG7960000
MSDS Information
Allylestrenol Usage And Synthesis
OriginatorAlilestrenol ,Terapia
UsesA synthetic steroid with progestational activity.
UsesAllylestrenol, is a synthetic sexualsteroid, that is used worldwide in case of endangered pregnancies.
DefinitionChEBI: Allylestrenol is a steroid. It derives from a hydride of an estrane.
Manufacturing ProcessTo 145 ml of dry methylamine which is cooled to -20°C 1.5 g of lithium cut to small pieces are added. To the solution which is blue in color after 10-20 min, a solution of 3.0 g of oestradiol-3-methylether in 145 ml of absolute ether is added drop wise. Subsequently the reaction mixture is stirred at -10°C for 40 h, after which 50 ml of absolute ethanol are added. Then the methylamine is distilled off at law pressure.
To the remaining solution 50 ml of ether and 50 ml of water are added. The water layer is separated and extracted with ether. The ethereal layer is washed with a 2 N hydrochloric acid solution, subsequently with a saturated sodium bicarbonate solution, and then with water. The ethereal solution is dried and evaporated to dryness. The resulting crude reaction product is dissolved in a mixture of benzene and petroleum ether (1:3) and chromatographed over aluminium oxide. The δ4-17β-hydroxy-oestrene obtained after chromatographic purification has a melting point of 80°-90°C and 95°-100°C after repeated crystallization from petroleum ether.
A solution of 13.2 g of chromium trioxide in a mixture of 120 ml of water and 20 ml of acetic acid is added, with stirring, to a solution of 20 g of δ4-17β- hydroxy-oestrene in 400 ml of benzene. Subsequently the reaction mixture is vigorously stirred at room temperature for 16 h, after which the benzene layer is separated.
The remaining aqueous layer is extracted a few times with benzene and the benzene extracts collected are then added to the separated benzene layer. The benzene extracts are successively washed with dilute sulfuric acid and water and then evaporated to dryness. The residue is crystallized from acetone, and the δ4-17β-oxo-oestrene, melting point 114°-116°C is obtained. To a mixture of 22.4 ml of absolute ether and 1.84 g of magnesium, a mixture of 2.72 ml of allyl bromide and 2.72 ml of absolute ether is added in nitrogen atmosphere. Subsequently a solution of 2 g of δ4-17β-oxo-oestrene in 30 ml of absolute ether is added to this reaction mixture, after which the whole is stirred for 4 h. Then the reaction mixture is poured into acidified ice water. The aqueous mixture is extracted with ether; the ether layer is separated, washed with water, dried over sodium sulfate and evaporated to dryness. The residue is recrystallized from a mixture of ether and petroleum ether, giving δ4-17β-hydroxy-17α-allyl-oestrene, melting point 79.5°-80°C.
Therapeutic FunctionProgestin; Antiandrogen
Allylestrenol Preparation Products And Raw materials
Raw materialsLithium-->Magnesium-->Acetic acid-->Allyl bromide-->Chromium(VI) oxide-->Methylamine-->lithium allyl
Tag:Allylestrenol(432-60-0) Related Product Information
Thiophanate-methyl Methyl acetate Kresoxim-methyl Methylparaben Bensulfuron methyl METSULFURON METHYL Methyl acrylate Gestonorone 17-Methyltestosterone Voglibose Methyl Methyl bromide Parathion-methyl ETHYLESTRENOL ESTRENONE ESTREN Allylestrenol Allylestrenol Impurity B