Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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Tel: |
821-50328103-801 18930552037 |
Email: |
3bsc@sina.com |
Products Intro: |
Product Name:Y-26763;N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-diMethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetaMide CAS:127408-31-5 Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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Company Name: |
BOC Sciences
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Tel: |
1-631-485-4226; 16314854226 |
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info@bocsci.com |
Products Intro: |
Product Name:Y-26763 CAS:127408-31-5 Purity:98% by HPLC Remarks:Y-26763 is a Kir6 (KATP) channel opener and active metabolite of Y-27152. Y-26763 inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Y-26763 exhibits antihyperte
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| N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Basic information |
Product Name: | N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE | Synonyms: | N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE;Y-26763;Acetamide, N-[(3S,4R)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxy-;Y 26763,Y26763 | CAS: | 127408-31-5 | MF: | C14H16N2O4 | MW: | 276.29 | EINECS: | | Product Categories: | Potassium channel | Mol File: | 127408-31-5.mol | ![N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Structure](CAS/GIF/127408-31-5.gif) |
| N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Chemical Properties |
Boiling point | 455.4±55.0 °C(Predicted) | density | 1.36±0.1 g/cm3(Predicted) | storage temp. | Store at RT | solubility | Soluble to 100 mM in 1eq. NaOH | form | Powder | pka | 8.69±0.60(Predicted) | color | Off-white to yellow |
| N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Usage And Synthesis |
Uses | Y-26763, is a Kir6 (KATP) channel opener. It also inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. In vivo, it has shown to have hypotension activity in rats and cardioprotective properties in dogs. | Definition | ChEBI: N-[(3S,4R)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl]-N-hydroxyacetamide is a 1-benzopyran. | Biological Activity | K ATP channel opener and active metabolite of Y-27152 (N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide ). In vitro, causes relaxation of contracted rat aortic rings (IC 50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic b-cells. In vivo, produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration. | storage | Store at RT |
| N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Preparation Products And Raw materials |
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